… mechanisms these conditions have in common. In addition to … relationships and identified
the putative mechanisms involving … disease association studies. Crucially, only one of the loci …

… Further we show an example that the identified trans-associations can be explained using
… Systematic identification of trans eQTLs as putative drivers of known disease associations. …

… are known to be therapeutically important and new putative … levels and across local and
systemic sites. Together, these data … Our pQTL study identified twice as many trans associations …

… in which eQTLs operate and systematically conducted MR … to identify independent
associations in each cis-eQTL locus. … on 228,819 variants with a known interpretation. This set …

… identify gene sets which have significant evidence of trans-association with groups of known
… To systematically evaluate this, we performed a differential expression enrichment analysis …

… disease, in particular autoimmunity. A Natural Killer cell transcriptome-wide association
study across five common autoimmune diseases … TMEM163 in systemic lupus erythematosus …

… are known to be therapeutically important, and new putative … However, systematic statistical
colocalization analyses using … Our pQTL study identified twice as many trans associations …

… difference, an implied eQTL because both alleles share a common environment in trans [ …
that can be evaluated for association with disease in GWAS studies. In essence, reference …

… We mapped the effects of nearby common genetic variants … have been performed to
systematically identify the function of … our trans association in other cell types using existing eQTL …

… mediated through weak trans-effects of common variants that coa… putative core genes could
be identified from associations of … , this study identifies nine top candidates as putative core …