Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

JM Eales, X Jiang, X Xu, S Saluja, A Akbarov… - Nature …, 2021 - nature.com
common complex human diseases 1 . Hypertension is a key … We also observed causal
association between higher SBP … have observational evidence of putative effects on BP regulatory …

[HTML][HTML] ADELLE: A global testing method for Trans-eQTL mapping

T Akinbiyi, MS McPeek, M Abney - bioRxiv, 2024 - ncbi.nlm.nih.gov
… For the moment, we take Ω as known, but we describe below how to … trans eQTL associations
in the hippocampus region and use summary statistics to test for trans eQTL associations

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

LM McGowan, G Davey Smith, TR Gaunt… - Human molecular …, 2019 - academic.oup.com
popular statistical method used to strengthen causal inference with respect to exposure–disease
associations … (or its receptor) is a putative driver of the IMD when it is expressed within …

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

E Porcu, S Rüeger, K Lepik, FA Santoni… - Nature …, 2019 - nature.com
… The putative causal associations reported in this study are not definitive. They provide a …
eQTL studies have been performed so far. Indeed, we failed to replicate the known association

Tissue-specific multi-omics analysis of atrial fibrillation

I Assum, J Krause, MO Scheinhardt, C Müller… - Nature …, 2022 - nature.com
identify core gene pathways and putative core genes for AF. As core genes are postulated
to have trans-associations … a bias towards already known disease gene set definitions, as for …

Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets

Z Dong, Y Ma, H Zhou, L Shi, G Ye, L Yang, P Liu… - BMC pulmonary …, 2020 - Springer
… of disease-associated common variants identified from … GWAS findings and predict putative
causal variants that were … 11 identified genes showed non-significant associations with …

MOSTWAS: multi-omic strategies for transcriptome-wide association studies

A Bhattacharya, Y Li, MI Love - PLoS genetics, 2021 - journals.plos.org
… Here, we refer to an eQTL as a SNP with an association with … conducted association tests
for known Alzheimer’s disease … of a total of 18 and 13 putative TWAS genes in each respective …

Genetic drivers of m6A methylation in human brain, lung, heart and muscle

X Xiong, L Hou, YP Park, B Molinie… - Nature …, 2021 - nature.com
association studies (GWAS) have identified >100,000 genetic loci associated with complex
traits and diseases, … of SNPs from eQTLs, thus expanding the set of genetic variants known to …

Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue

A Díez-Villanueva, M Jordà, R Carreras-Torres… - Clinical …, 2021 - Springer
… Bayesian networks have been used to identify putative … In this study, our objectives were to
map common genetic variation … -associations, though there might be other significant eQTLs, …

A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci

X Chang, M March, F Mentch, K Nguyen… - Journal of Allergy and …, 2022 - Elsevier
… into the genetic etiology driving the pathogenesis of EoE and … eQTL analysis also indicated
a significant association between … Besides the aforementioned 6 common loci, we identified 5 …