… human cell types To identify accessible chromatin regions in each of the 111 cell types, we
aggregated chromatin accessibility … We then merged these accessible chromatin regions to …

… Most single-nucleotide polymorphisms (SNPs) in the human genome occur in non-coding
and intergenic genomic regions and individually contribute small or indirect effects to complex …

… The chromatin landscape at the local level—the focus of this Review (Box 2)—is dominated
by the alternation of nucleosomes and linkers, interspersed with nucleosome-free regions …

… The development of high-throughput chromatin conformation assays (for example, Hi-C 1 …
3D organization of the human genome and how it influences gene regulation. Topologically …

… profiling methods may serve as an analytic foundation to identify regulatory regions, it is
reported that often less than 50% of accessible regions in human DNA are active as enhancers …

… regions that we identified spans 17% of the human genome, which is in line with recent
bulk DNase-seq profiles from fetal tissues (91). Most of these ~1 million elements are cell type–…

… The sequenced paired-end reads were mapped to the UCSC human genome version 37
(hg19) using the local alignment option of bowtie2 with following parameters—very-sensitve-…

… To study the impact of genetic variation on the chromatin landscape, we used allele-specific
measurement of open chromatin to identify genotype-dependent sites (ASCs). While the …

… Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

… To systematically annotate candidate target genes for the cREs in the human genome,
we performed capture Hi-C experiments (Fig. 1a and Supplementary Fig. 1) to interrogate …