Spatial chromatin architecture alteration by structural variations in human genomes at the population scale

M Sadowski, A Kraft, P Szalaj, M Wlasnowolski, Z Tang… - Genome biology, 2019 - Springer
… of SVs on the 3D chromatin organization of the human genome, we pay a specific attention
to chromatin interactions associated with enhancer regions and gene promoters. These …

The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease

J Bendl, ME Hauberg, K Girdhar, E Im, JM Vicari… - Nature …, 2022 - nature.com
… of genomic assays in the Mount Sinai Brain Bank AD (MSBB-AD) cohort 9 . In particular, we
generated genome-wide maps of chromatin accessibility … 79 to human genome hg38 using …

Physical nature of chromatin in the nucleus

K Maeshima, S Iida, S Tamura - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
… However, the memory density of the human genome in the nucleus can be calculated as
∼7.5 × 10 14 bytes/mm 3 , considering that the nuclear volume is roughly 1000 µm 3 . This …

Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq

S Ma, Y Zhang - Molecular biomedicine, 2020 - Springer
… scChIP-seq enables the clustering of cell populations based on the diversity of the chromatin
landscape and the identification of chromatin features specific to each population, such as …

Biophysics of chromatin dynamics

B Fierz, MG Poirier - Annual review of biophysics, 2019 - annualreviews.org
… Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

[HTML][HTML] A chromatin accessibility atlas of the developing human telencephalon

E Markenscoff-Papadimitriou, S Whalen, P Przytycki… - Cell, 2020 - cell.com
… and distance to gene TSS in the human genome: OCRs that do not change chromatin
accessibility between 14 gw and 18 gw in the PFC, OCRs that gained accessibility from 14 gw to …

[HTML][HTML] A unique epigenomic landscape defines human erythropoiesis

VP Schulz, H Yan, K Lezon-Geyda, X An, J Hale… - Cell reports, 2019 - cell.com
… , we performed genome-wide studies of chromatin accessibility, DNA methylation, and …
human erythroid cells. The integration of gene expression, DNA methylation, and chromatin state …

High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

S Chen, BB Lake, K Zhang - Nature biotechnology, 2019 - nature.com
… To evaluate the ability of SNARE-seq to capture accessible chromatin, we first performed a
… characterized chromatin landscapes. Ensemble profiles of SNARE-seq accessibility data …

Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts

S Nair, DS Kim, J Perricone, A Kundaje - Bioinformatics, 2019 - academic.oup.com
… We bin the human genome (GRCh37 assembly) into 200 bp bins (⁠ i ⁠) every 50 bp. For
each of the 123 cellular contexts (⁠ j = { 1 … 123 } ⁠), all bins are assigned binary labels (⁠ y i …

An atlas of dynamic chromatin landscapes in mouse fetal development

DU Gorkin, I Barozzi, Y Zhao, Y Zhang, H Huang… - Nature, 2020 - nature.com
… 3) We further required that the human gene Ensembl ID mapped uniquely to one mouse
Ensembl ID. 4) Finally, we considered only autosomes, because of the mixed-gender litter pools …