… All modern vaccines work by tricking our immune system into developing “immunologic
memory” against a specific infectious pathogen. This immunologic memory is mediated by B and …

… personalized vaccine development (ie, vaccines developed … aging immune system and
highlighting promising approaches to further vaccine research efforts in support of healthy aging. …

… Age is an important factor that influences vaccine responses, … Infants should receive
immunizations as early as possible to … vaccine in relation to the effect of age on vaccine …

… to mount effective responses to vaccines. Immunosenescence and inflamm-… vaccine
approaches underway including antivirals and immune-modulating agents, and immune response …

… reported that immune-aging is an important factor in the increased susceptibility of older
adults to infection 19 as well as their poor vaccination responses. Immune-aging is strongly …

… individuals above eighty years of age 1 . Here we analysed immune responses following
vaccination with the BNT162b2 mRNA vaccine 2 in elderly participants and younger healthcare …

… vaccination responses are impaired with increasing age is … after the second vaccination for
the elderly group of vaccinees … into age-dependent limitations of immune responses elicited …

… Enhancing the efficacy of the adaptive immune response … of immunity upon vaccination, while
inhibiting inflamm-aging will … In general, elderly individuals are less able to respond to neo-…

… As we age, both the immune system and the gut microbiome … vaccination responses. Emerging
studies suggest that targeting … and mount appropriate vaccination responses as we age. …

… important immune response regulator, notably in vaccine … effect of Vit-D on cell-mediated
immunity (44). Increased IDO activity has been associated with tolerogenic immune responses (…