A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

A Alpert, Y Pickman, M Leipold… - Nature medicine, 2019 - nature.com
… the immune system and survival, we expect that IMM-AGE … as part of an influenza vaccine
study; individuals were requested … -flow cytokine responses that changed significantly with age, …

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
… present in higher numbers in the elderly, negatively impact T cell responses to SARS-CoV-2.…
the impact of intervening vaccines and other factors that also modulate the immune system. …

Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors

RT Shroff, P Chalasani, R Wei, D Pennington… - Nature medicine, 2021 - nature.com
… Participants were not informed of their immune response results. … There did appear to be an
age-moderated effect within the … we did not observe age-moderated effects within the cancer …

Contributions of age-related thymic involution to immunosenescence and inflammaging

R Thomas, W Wang, DM Su - Immunity & Ageing, 2020 - Springer
… all age-related changes to the immune system, … immune responses to new infection or
vaccination, and diminished anti-tumor immunosurveillance, including altered immune response

Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
… the protective and inflammatory responses and COVID-19 … risk factors such as gender
and age. Diabetes, cardiovascular … vaccine, one that would have minimal side effects (139). …

Evaluation of immune response and disease status in systemic lupus erythematosus patients following SARS–CoV‐2 vaccination

PM Izmirly, MY Kim, M Samanovic… - Arthritis & …, 2022 - Wiley Online Library
… second dose of the vaccine, incomplete vaccination schedule, and … Healthy controls were
≥18 years of age, had no known … inefficient immune responses to COVID vaccination, it may …

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

J Wei, KB Pouwels, N Stoesser, PC Matthews… - Nature Medicine, 2022 - nature.com
… anti-trimeric spike IgG antibody responses after second ChAdOx1 or BNT162b2 vaccinations,
and we quantified the effect of dosing interval, age and prior infection status on antibody …

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

KJ Selva, CE Van De Sandt, MM Lemke, CY Lee… - Nature …, 2021 - nature.com
… in elderly, while children have stronger Fc responses which we … These insights will inform
COVID-19 vaccination strategies, … humoral immune response after infection and/or vaccination

Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

C Bergamaschi, E Terpos, M Rosati, M Angel, J Bear… - Cell reports, 2021 - cell.com
responses to vaccination are important for shaping both humoral and cellular protective
immunity… Here, we characterize the cytokine and chemokine responses to the 1 st and 2 nd dose …

Waning immunity after the BNT162b2 vaccine in Israel

Y Goldberg, M Mandel, YM Bar-On… - … England Journal of …, 2021 - Mass Medical Soc
effect of the vaccination period for each age group was allowed by the inclusion of an interaction
term between age and vaccination … Positivity on the polymerase-chain-reaction (PCR) …