What role does the endocannabinoid system play in the pathogenesis of obesity?

P Schulz, S Hryhorowicz, AM Rychter, A Zawada… - Nutrients, 2021 - mdpi.com
… that other types of cannabinoid receptors, nonCB 1 and … , which can affect the nutritional
status, energy balance, lipoprotein … Thus, the orexigenic effect of CB 1 has been associated with …

Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis

Y Yong, I Cakir, P Lining Pan… - Proceedings of the …, 2021 - National Acad Sciences
… presynaptic Giα-coupled cannabinoid receptors, mainly the CB1 … in energy balance
parameters, we reconstituted the … mice indicates that the anorexigenic effect of DO34 depends on …

The Peripheral Cannabinoid Receptor Type 1 (CB1) as a Molecular Target for Modulating Body Weight in Man

SE O'Sullivan, AS Yates, RK Porter - Molecules, 2021 - mdpi.com
… , CB 1 receptor activation impacts the energy balance of mammals in a … Thus, the anorexigenic
effect of CB 1 antagonists is at least … cannabinoid receptors can also be achieved through

Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

I Ruiz de Azua, B Lutz - Cellular and molecular life sciences, 2019 - Springer
… others, as an important endogenous orexigenic signal. It is … can target other receptors than
cannabinoid receptors, such … revealed the control of energy balance through the regulation of …

Role of the endocannabinoid system in the adipose tissue with focus on energy metabolism

V Rakotoarivelo, J Sihag, N Flamand - Cells, 2021 - mdpi.com
… , the eCB system influences energy balance by regulating … induces an orexigenic effect in
the central nervous system [236,… Several drugs targeting either the cannabinoid receptors or …

Hypothalamic endocannabinoids in obesity: an old story with new challenges

C Miralpeix, AC Reguera, A Fosch, S Zagmutt… - Cellular and Molecular …, 2021 - Springer
… a critical role in regulating energy balance through central and peripheral … Cannabinoid and
non-cannabinoid receptors … to observe the orexigenic effects of the endocannabinoids [79]. …

Central Nervous System Regulation of Energy Balance and Energy Stores

JM Gonzalez-Campoy - … and Management of Adiposity, Adiposopathy and …, 2019 - Springer
… , tonic upregulation of orexigenic signals and downregulation of anorexigenic signals, …
endogenous lipid-based retrograde neurotransmitters. There are two major cannabinoid receptors

Understanding the possible role of endocannabinoid system in obesity

T Behl, S Chadha, M Sachdeva, A Sehgal… - Prostaglandins & Other …, 2021 - Elsevier
… known for exerting crucial role in regulating energy balance. … Therefore, orexigenic action
of endocannabinoids appears to … regulates through the interaction of cannabinoid receptors, …

Role of the endocannabinoid system in metabolic control processes and in the pathogenesis of metabolic syndrome: an update

G Dörnyei, Z Vass, CB Juhász, GL Nádasy, L Hunyady… - Biomedicines, 2023 - mdpi.com
… food intake, upregulating energy balance and fat accumulation, … ) serve as endogenous
ligands for cannabinoid receptors and … stimulation of CB 1 Rs activate hypothalamic orexigenic

Endocannabinoid system in the regulation of appetite with pharmaceutical applications

A Vuori - 2023 - trepo.tuni.fi
… While cannabinoid receptors are present in multiple organs … attenuated leptin’s anorexigenic
effects, which indicates that … in growth, sex development, energy balance, and appetite. As …