… drug-resistantmalaria urgently requires the development of new antimalarial drugs with novel modes of action. … on modes of action of and mechanisms of resistance to ACT drugs. …
… mechanisms of drugaction and resistance, as well as general Plasmodium biology. Insights gleaned from such experiments will continue to prove invaluable in the exploration and …
LS Ross, DA Fidock - Cell host & microbe, 2019 - cell.com
… malaria. However, drugresistance threatens to derail this progress. In this review, we present four antimalarial resistance case studies that differ in timeline, technical approaches, …
B Hanboonkunupakarn, J Tarning… - Frontiers in …, 2022 - frontiersin.org
… While the world is aiming to eliminate malaria, artemisinin resistance … mechanismof artemisinin resistance and the potential changes needed in the treatment regimens to fight resistance…
MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
… effect against drug-resistantmalaria parasites, and also able to reduce the parasite burden in asymptomatic individuals who serve as reservoirs for malaria … fast-acting drugs that cause …
… drugs used for chemoprevention is perennially threatened by drugresistance. This review … and spread of drugresistantmalaria, and the impact of drugresistance on the efficacy of each …
K Carolino, EA Winzeler - Current opinion in microbiology, 2020 - Elsevier
… find compounds effective at specifically clearing malaria-causing Plasmodium parasites at any … or mode of action. Here, we review recent advances in antimalarial drug discovery efforts, …
… of drug-resistantmalaria and their impacts on past control efforts, a brief overview of mechanisms of resistance, methods of drugresistance surveillance, the effects of resistance on …
AN Cowell, EA Winzeler - Briefings in functional genomics, 2019 - academic.oup.com
… This is especially useful since empirical testing for drugresistance, either in patients or after … malaria-endemic regions. Our understanding of the mechanisms of antimalarial resistance is …