An overview of available antimalarials: discovery, mode of action and drug resistance

YQ Tang, Q Ye, H Huang… - Current Molecular …, 2020 - ingentaconnect.com
… To assist Vietnam, China provided substantial material support, including the development
and provision of antimalarial drugs for the treatment of chloroquine-resistant malaria strains …

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
drug-resistant malaria urgently requires the development of new antimalarial drugs with
novel modes of action. … on modes of action of and mechanisms of resistance to ACT drugs. …

Genomic approaches to drug resistance in malaria

F Rocamora, EA Winzeler - Annual Review of Microbiology, 2020 - annualreviews.org
mechanisms of drug action and resistance, as well as general Plasmodium biology. Insights
gleaned from such experiments will continue to prove invaluable in the exploration and …

Elucidating mechanisms of drug-resistant Plasmodium falciparum

LS Ross, DA Fidock - Cell host & microbe, 2019 - cell.com
malaria. However, drug resistance threatens to derail this progress. In this review, we
present four antimalarial resistance case studies that differ in timeline, technical approaches, …

Artemisinin resistance and malaria elimination: Where are we now?

B Hanboonkunupakarn, J Tarning… - Frontiers in …, 2022 - frontiersin.org
… While the world is aiming to eliminate malaria, artemisinin resistancemechanism of artemisinin
resistance and the potential changes needed in the treatment regimens to fight resistance

Antimalarial drug resistance and novel targets for antimalarial drug discovery

MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
effect against drug-resistant malaria parasites, and also able to reduce the parasite burden
in asymptomatic individuals who serve as reservoirs for malaria … fast-acting drugs that cause …

Malaria chemoprevention and drug resistance: a review of the literature and policy implications

CV Plowe - Malaria Journal, 2022 - Springer
drugs used for chemoprevention is perennially threatened by drug resistance. This review …
and spread of drug resistant malaria, and the impact of drug resistance on the efficacy of each …

[HTML][HTML] The antimalarial resistome–finding new drug targets and their modes of action

K Carolino, EA Winzeler - Current opinion in microbiology, 2020 - Elsevier
… find compounds effective at specifically clearing malaria-causing Plasmodium parasites at
any … or mode of action. Here, we review recent advances in antimalarial drug discovery efforts, …

Antimalarial drug resistance and implications for the WHO global technical strategy

MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
… of drug-resistant malaria and their impacts on past control efforts, a brief overview of
mechanisms of resistance, methods of drug resistance surveillance, the effects of resistance on …

The genomic architecture of antimalarial drug resistance

AN Cowell, EA Winzeler - Briefings in functional genomics, 2019 - academic.oup.com
… This is especially useful since empirical testing for drug resistance, either in patients or after
malaria-endemic regions. Our understanding of the mechanisms of antimalarial resistance is …