… Results from animal studies suggest that neuroprotective agents can prevent brain damage
… to propose new neuroprotective combination therapies for stroke that overcome the failure of …

… stroke studies before conducting experiments on a common database. Thus, a track on all
studies … but would also incline our approach towards newer therapeutic targets, which can be …

… the obvious and well-documented mistakes made in neuroprotection preclinical studies and
… Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… who have had a stroke, few therapeutic options exist. The vast … is evidence of a move towards
human-focused approaches … of neuroprotection 51 even after the failure of the SAINT-II trial…

… to acute reperfusion and neuroprotection strategies. Those … of recovery, many early trials
failed to measure true recovery … a critical period after stroke, therapies may be high dose and …

… Human clinical trials have often failed to start therapies in the … adverse event was a trend
toward increased mild renal impair… Accordingly, a neuroprotective benefit of this agent class has …

… We review lessons learned from the ongoing work of the pre-… important, recent studies in the
field of stroke have suggested … to development of new neuroprotective therapies to address …

… Thus, failing to use randomization and blinding could lead to … 50% of published ICH
neuroprotection studies make use of 2 … neuroprotection studies do not consider realistic …

… investigation, such widely reported failures contribute to a declining … ischemic stroke, dozens
of pivotal clinical trials have failed … There is a publication bias toward reporting statistically …

… and/or neuroprotection interventions have failed or cannot be … circulation showed a trend
toward better recovery with … At the end of this review of AIS and head injuries, certain lessons …