… neural repair and neuroprotection after stroke. Finally, we … phase II trial involving 118
patients with recent ischemic stroke … learning in preclinical studies [37, 38] and in patients with …

… neuroprotective treatment, translational research is still needed to bridge our evolving and
deeper understanding of stroke mechanisms with lessons … of neuroprotection trials in stroke, …

… with CTs in stroke, as early studies have demonstrated safety and a trend towards functional
… walking training and circuit class therapy, ideally initiated early after stroke. Multiple reviews …

… that primarily enhance effector-independent learning. … following stroke is ≥30% (Hammerbeck
et al., 2019). Its presence is frequently grounds for exclusion from trials of the therapies …

… the stroke class and time course are fitting [Citation74]. According to many studies,
autophagy-targeted therapy … modulating neuroprotective agent potentially capable of treating …

… the major clinical trials of cell therapy for stroke and highlight … to ischemic injury, but their
failure to demonstrate efficacy led … toward using various stem cells that secrete neuroprotective …

… In various studies on neuroprotection, it was observed that … All advanced to and failed phase
III clinical trials due to poor … Immunophilin ligands are another class of studied therapeutics. …

… may provide new targets for the neuroprotective effects of … on neuronal excitability and spatial
learning in the EC where … known to be elevated after stroke, and recent studies from our lab …

… All the trials failed, for several reasons, 4 perhaps the main one … of stroke offer another
promising area for treatment and … We aimed to find out why and help apply the lessons across …

… What can we learn from this trial? Several issues emerge … be preferable for initial trials
translating stroke recovery therapies. … towards these goals and can inform trial design for stroke …