… of neuroprotective drugs in pre-clinical studies and the lack of effect in clinical trials of stroke
… -1 involved in autophagy regulation [65], and class I PI3Ks are involved in the Akt activation […

… A first group of papers focused on stroke, neuroprotection, … studies provided very little
hints for human therapy, because … of motor learning and stroke recovery and present a new …

… In any case, despite the seeming failure of PEG-SOD in human TBI, experimental studies …
studies have demonstrated neuroprotective efficacy in a rodent ischemia-reperfusion stroke …

… and neuroprotection, as well as a lower risk and severity of stroke 25 . … The class I PI3K
complex suppresses while the class III PI3K … Several clinical trials have revealed the benefits of …

… the so-called neuroprotective drugs have failed in clinical trials, … single neuroprotective drug
therapies have failed in stroke. … To learn about our use of cookies and how you can manage …

… Therefore, we used rats to evaluate the neuroprotective effect at the chronic phase of stroke.
… Toward wisdom from failure—lessons from neuroprotective stroke trials and new therapeutic …

… therapeutic strategies are delivered in human stroke patients… The design of clinical trials
in human stroke patients will not … A multivariate machine learning technique was used to …

… and clinical studies exploring neuroprotection for stroke, no neuroprotective therapy has …
One can summarize the translational failures of preclinical trials reported by Chamorro as …

… AM, for the Heart and Stroke Foundation of Ontario Centre of Excellence in Stroke Recovery…
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… ) is among the most potent neuroprotective therapies studied in … in trials of TH for global
cerebral ischemia and stroke. We … trials published to date (stroke, head trauma), TH has failed to …