… AM, for the Heart and Stroke Foundation of Ontario Centre of Excellence in Stroke Recovery…
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… stroke studies revealed … Neuroprotection was also achieved by the FIASMA fluoxetine
at a dose of 5 mg/kg or 10 mg/kg after MCAO in rats, if treatment was started 6 h or 9 h post-stroke, …

… ) is among the most potent neuroprotective therapies studied in … in trials of TH for global
cerebral ischemia and stroke. We … trials published to date (stroke, head trauma), TH has failed to …

… a new therapeutic class of agents for the treatment of a vast … The Gottigen EPO proof of
principle stroke trial, restricted to a … The first metabolic failure in stroke is Na/K pump, following …

… , to a failure to conform with the Stroke Therapy Academic … Most studies of C21 as a
neuroprotective agent in stroke … found that treatment with tPA at 4 h results in a trend toward higher …

… studies on the mechanism of neuroprotection induced by exercise, providing the theoretical
basis of applying exercise therapy to prevent and treat ischemic stroke. In … -based learning in …

… important roles in motor learning. Amphetamine increases … ischemic model in a non-neuroprotective
manner 43 and that … trial of intraarterial treatment for acute ischemic stroke.N Engl …

… clinical trial protocol that evaluates the neuroprotective effect … two sub-studies: one used a
machine learning approach to … growing body of neuroprotective clinical trials that have failed to …

… on the former because no neuroprotection strategies have been … trial, several other trials
attempted to extend the therapeutic … Toward wisdom from failure: lessons from neuroprotective …

… Neuroprotection includes all therapies aimed at reducing cell … clinical trials, so the search
for new therapeutic strategies is … plays an essential role in learning and memory. Other …