… Animal studies have correlated these infarcts with future strokes and behavioral … in the
main ENACT trial results), around 3.5 infarcts on average, we did not find treatment effects with …

… Overall, this study identifies a novel neuroprotective … studies of potential stroke therapies to
address both variables. … a Kaplan–Meier survival plot shows a trend toward greater mortality …

… continues to face repeated translational failures. Brain … aim of neuroprotective treatment of
stroke is to expand the … for critical design of future therapeutic studies to prove the potential …

… permanent ischemic stroke in animal models 14 but failed to … of these studies was to establish
whether NIR treatment limits … NIR treatment paradigm evoked sustained neuroprotection in …

… antagonists failed to show efficacy in clinical trials of stroke or … Therefore, new therapeutic
strategies aimed at reducing … Several papers in the literature report the neuroprotective effect of …

… studies. In the clinic, there is always a critical time window for rehabilitation intervention ( …
be developed into a practical therapeutic strategy for treating intractable stroke, we studied the …

… Thus, numerous neuroprotective therapies aiming at cerebral gray matter injury (not …
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… This chapter begins by discussing cerebral metabolism and energy failure, followed by a …
Toward wisdom from failure lessons from neuroprotective stroke trials and new therapeutic …

… of ischemic and hemorrhage stroke, traumatic spinal cord … Based on the results of these
studies, we then measured … Lastly, we examined the neuroprotective potential of Ru265 in …

… warrants the promising therapy for stroke with TMP treatment. … neuroprotective agents show
potential effects against cerebral ischemia in experimental rodents but failed in clinical trials (…