… of failed neuroprotection trials, evidence-based treatments for acute ischaemic stroke finally
… to posterior circulation stroke too [98], more work is needed towards formal validation and …

… This article reviews how this idea arose from GWAS studies, … are available, and most
studies have used class IIa inhibitors, … to have a neuroprotective role in acute ischemic stroke, …

… shown in several studies to provide neuroprotection against ischemic insults in stroke models
and other … Furthermore, ERβ but not ERα agonist improved spatial learning performance in …

… brain injury induced by ischemic stroke. However, the role and … Similarly, in vitro studies
showed that OGD reduced GluA1 … In addition, the neuroprotective effect of AC-YVAD-CMK was …

… on the new techniques that are used for neuroprotection and … In the last few years, new
therapeutic strategies—ie, … after stroke and hence the major part of the available studies has …

… In the present study, long-term neuroprotective effects of LPA 5 antagonism were …
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… therapeutic intervention against ischemic stroke is the lack of … structures, numerous functions
(learning, memory, movement) … We expect further studies in the near future, both in the field …

… SE, Hakim AM, Heart and Stroke Foundation of Ontario Centre of Excellence in Stroke R…
Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic …

… categorised into four distinct classes, namely class I, II and IV, … can provide neuroprotection
following ischaemic stroke, but … The study reports that fail to include results for neither infarct …

… employed to treat high prevalent brain pathologies such as stroke, Alzheimer’s … failed in
clinical trials, reducing our expectations of quickly discovering effective neuroprotective therapies…