Background In the past 20 years four major viral infectious diseases outbreaks caused
hundreds of thousands of deaths worldwide: SARS, Influenza H1N1, MERS, and COVID-19.
They all present clinically initially as upper and lower respiratory tract infections and may
progress to multi-organ failure. Methods This study was a systematic review of literature
conducted in September 2020 to study extra-pulmonary complications of SARS, FLU,
MERS, and current COVID-19. We carried out a systematic search using the keywords in …

Abstract Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses
a threat to humanity. However, no specific therapy has been established for this disease yet.
We conducted a systematic review to highlight therapeutic agents that might be effective in
treating COVID-19. Methods: We searched Medline, Medrxiv. org, and reference lists of
relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments
for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) …