Viral infection neutralization tests: A focus on severe acute respiratory syndrome‐coronavirus‐2 with implications for convalescent plasma therapy
Reviews in medical virology, 2021•Wiley Online Library
Viral neutralization tests (VNTs) have long been considered old‐fashioned tricks in the
armamentarium of fundamental virology, with laboratory implementation for a limited array of
viruses only. Nevertheless, they represent the most reliable surrogate of potency for passive
immunotherapies, such as monoclonal or polyclonal antibody therapy. The recent interest
around therapy with convalescent plasma or monoclonal antibodies for the Covid‐19
pandemic has paralleled the revival of VNTs. We review here the available methods by …
armamentarium of fundamental virology, with laboratory implementation for a limited array of
viruses only. Nevertheless, they represent the most reliable surrogate of potency for passive
immunotherapies, such as monoclonal or polyclonal antibody therapy. The recent interest
around therapy with convalescent plasma or monoclonal antibodies for the Covid‐19
pandemic has paralleled the revival of VNTs. We review here the available methods by …
Summary
Viral neutralization tests (VNTs) have long been considered old‐fashioned tricks in the armamentarium of fundamental virology, with laboratory implementation for a limited array of viruses only. Nevertheless, they represent the most reliable surrogate of potency for passive immunotherapies, such as monoclonal or polyclonal antibody therapy. The recent interest around therapy with convalescent plasma or monoclonal antibodies for the Covid‐19 pandemic has paralleled the revival of VNTs. We review here the available methods by dissecting variations for each fundamental component of the VNT (i.e., virus type and dose, replication‐competent cell line, serum, and detection system).
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