Characteristics and clinical outcome in 312 patients with moderate to severe pneumonia due to SARS-COV-2 and hyperinflammation treated with anakinra and …

IF Aomar-Millán, JM de Victoria-Carazo… - Plos one, 2023 - journals.plos.org
… This trial demonstrated a 64% reduction in clinical worsening and a 55% reduction in death
on day 28, as well as an 80% reduction in patients with laboratory criteria for cytokine storm

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
… In this way, the model presented here explains why there is not, and can never be, a
universal definition of a “cytokine storm”, nor a single set of clinical criteria for diagnosis. Each …

Use of tocilizumab for COVID-19-induced cytokine release syndrome: a cautionary case report

J Radbel, N Narayanan, PJ Bhatt - Chest, 2020 - Elsevier
clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. These cases
highlight the need for clinical … Our report further challenges the clinical usefulness of anti-IL-6

Elevated levels of pleiotropic interleukin-6 (IL-6) and interleukin-10 (IL-10) are critically involved with the severity and mortality of COVID-19: An updated longitudinal …

S Jafrin, MA Aziz, MS Islam - Biomarker Insights, 2022 - journals.sagepub.com
… is cytokine storm, a hyperinflammatory process of cytokine … Inflammatory cytokines, more
specifically interleukins, are … in serum IL-6 and IL-10 worsens COVID-19 clinical outcomes. …

Biomarkers for early diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients

F Debaugnies, B Mahadeb, C Nagant… - Journal of clinical …, 2021 - Springer
… of a cytokine storm syndrome before progression to life threatening, multiple organ dysfunction
remains a clinical … The cytokine storm syndrome encompasses familial and secondary …

[HTML][HTML] Two novel nomograms based on inflammatory cytokines or lymphocyte subsets to differentially diagnose severe or critical and Non-Severe COVID-19

Z Li, N Jiang, X Li, B Yang, M Jin, Y Sun, Y He… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… that systemic inflammation responses, cytokine storms and dysregulated immune responses
occurred and exerted combined effects on the clinical progression in COVID-19, which …

Mesenchymal stem cell derived-exosomes as effective factors in reducing cytokine storm symptoms of COVID-19

AH Kheirkhah, SH Shahcheraghi… - Protein and Peptide …, 2021 - ingentaconnect.com
cytokine storms, the use of immune-boosting systems may be suggested as another way to
control cytokine storm. … of a randomized, double-blind clinical trial, placebo control with FDA …

The role of immunological and clinical biomarkers to predict clinical COVID-19 severity and response to therapy—a prospective longitudinal study

A Copaescu, F James, E Mouhtouris, S Vogrin… - Frontiers in …, 2021 - frontiersin.org
cytokine storm (4) and no occult sepsis (negative procalcitonin). A 5-day course of remdesivir
and/or dexamethasone for up to 10 days was administered to patients with severe disease …

Suppressive effects of sunitinib on a TLR activation-induced cytokine storm

S Zhao, N Gao, H Qi, H Chi, B Liu, B He, J Wang… - European Journal of …, 2019 - Elsevier
… The cytokine storm includes a clinically … on the cytokine storm induced by TLR ligands,
primarily through PDGFR pathways, which could be potentially used to reduce cytokine storms in …

[HTML][HTML] Favorable anakinra responses in severe Covid-19 patients with secondary hemophagocytic lymphohistiocytosis

G Dimopoulos, Q de Mast, N Markou… - Cell host & …, 2020 - cell.com
… Considering these limitations, the presented data in patients with severe COVID-19 and
sHLH warrant larger clinical trials to validate these results and to demonstrate the usefulness of …