Pyrrolo [2, 3-b] quinoxalines in attenuating cytokine storm in COVID-19: their sonochemical synthesis and in silico/in vitro assessment

R Chemboli, R Kapavarapu, K Deepti… - Journal of Molecular …, 2021 - Elsevier
… Recently, PDE4 inhibitors have been suggested to attenuate the cytokine storm in COVID-19
especially tumour necrosis factor alpha (TNF-α). In our effort we have explored the 2-…

Severe COVID-19, another piece in the puzzle of the hyperferritinemic syndrome. An immunomodulatory perspective to alleviate the storm

P Ruscitti, O Berardicurti, P Di Benedetto… - Frontiers in …, 2020 - frontiersin.org
… pro-inflammatory mediators, and the development of cytokine storm syndrome. On these
bases, it is reasonable to postulate the clinical usefulness of IL-1 β, IL-6, and IFN-y inhibition on …

Clinical Usefulness of T-Cell Receptor Vβ Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock …

S Kaneko, Y Noguchi, M Hatano… - The Pediatric …, 2024 - journals.lww.com
… T-cell hyperactivation and cytokine storms, leading to shock syndrome. Previously, we reported
that patients with MIS-C showed a similar pattern of serum cytokine profile to TSS caused …

… Approach to Slow Down the Inflammatory Cascade in Sepsis Appropriate Exogenous Local Inflammatory Response Impeded the Role of Large-Scale Cytokine Storm

M Gong, S Qi, Z Wu, Y Huang, L Wu, X Wang… - Available at SSRN … - papers.ssrn.com
… The emergence of severe sepsis is contingent upon the occurrence of a cytokine storm
18 … In this experiment, we ran a clinically oriented study to evaluate how turning 693 …

Efficacy of MSC in patients with severe COVID-19: analysis of the literature and a case study

M Grumet, J Sherman, BS Dorf - Stem cells translational …, 2022 - academic.oup.com
… between cytokine storms and ARDS. We propose that markers for cytokine storm are leading
… Considering that cytokine storm is a major target for MSC in clinical trials in GvHD and non-…

Fraxin in Combination with Dexamethasone Attenuates LPS‐Induced Liver and Heart Injury and Their Anticytokine Activity in Mice

NS Shaker, HB Sahib - Advances in Virology, 2023 - Wiley Online Library
… an anticytokine storm agent and the involvement of IL-8 in cytokine storms. … usefulness of
these agents in treating hyperinflammatory diseases, such as cytokine storms, in future clinical

Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose (2-DG) Cure COVID-19?

S Shrivastava, A Kumar, M Kumar Jeengar… - …, 2024 - ingentaconnect.com
… The clinical spectrum of the COVID-19 disease, which includes (inflammation, cytokine storm,
and multi-organ dysfunction), puts Corona Warriors active in various aspects of the disease…

Repurposing approved drugs on the pathway to novel therapies

CH Schein - Medicinal research reviews, 2020 - Wiley Online Library
… Thalidomide also alleviates the cytokine storm induced by bacterial infections.29 Animal
studies … Side effects may also limit the clinical usefulness of a variety of off-the (drug-)-shelf …

Colchicine as a potential therapeutic agent against cardiovascular complications of COVID-19: an exploratory review

C Papadopoulos, D Patoulias, E Teperikidis… - … Comprehensive Clinical …, 2020 - Springer
… The focus of this report is on the exaggerated host inflammatory response, most often
described as a cytokine storm that is reported in critically ill patients [5]. This seems to play a major …

Stem Cell Secretome Modulated by Arsenicum album 30C Ameliorates Lipopolysaccharide-induced Cytokine Storm in Blood Mononuclear Cells in vitro

P Aphale, A Sanap, D Sharma, A Kharat, S Kheur… - …, 2023 - thieme-connect.com
cytokine release alternatively known as a ‘cytokine storm’[2]. SARS-CoV-2-mediated cytokine
storms … to be validated further in pre-clinical models and in clinical trials, including those of …