COVID-19, mast cells, cytokine storm, psychological stress, and neuroinflammation

D Kempuraj, GP Selvakumar, ME Ahmed… - The …, 2020 - journals.sagepub.com
… Therapeutic options are now limited to COVID-19. The hallmark of COVID-19 pathogenesis
is the cytokine storm with elevated levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-…

[HTML][HTML] Cytokine storm and immunomodulatory therapy in COVID-19: role of chloroquine and anti-IL-6 monoclonal antibodies

M Zhao - International journal of antimicrobial agents, 2020 - ncbi.nlm.nih.gov
… of the role of immunomodulatory agents to reduce the cytokine storm in severe cases of
COVID-19. … Thus, cytokine storms should not be neglected in the treatment of COVID-19. …

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, X Nie… - …, 2020 - thelancet.com
… and treatment of severe patients with COVID-19. In this study, we investigated the critical
pathological changes in the lung of severe COVID-19 patients. We hope this work may …

Calming the cytokine storm in COVID-19

RQ Cron, R Caricchio, WW Chatham - Nature medicine, 2021 - nature.com
… Many who die from COVID-19 suffer hyper-inflammation with features of cytokine storm
syndrome (CSS) and associated acute respiratory distress syndrome 1,2 . Although the …

COVID-19: consider cytokine storm syndromes and immunosuppression

P Mehta, DF McAuley, M Brown, E Sanchez… - The lancet, 2020 - thelancet.com
… As of March 12, 2020, coronavirus disease 2019 (COVID-19) … with severe COVID-19 might
have a cytokine storm syndrome. We … Current management of COVID-19 is supportive, and …

An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis

Y Liu, D Chen, J Hou, H Li, D Cao, M Guo, Y Ling… - Cytokine, 2021 - Elsevier
Cytokine storm is associated with a poor disease prognosis [9], [10]. We monitored … cytokines
in 52 hospitalized patients with COVID-19. We initially compared maximal plasma cytokine

Features of cytokine storm identified by distinguishing clinical manifestations in COVID-19

WX Shen, RC Luo, JQ Wang, ZS Chen - Frontiers in public health, 2021 - frontiersin.org
… Following the above model, we proposed that cytokine storm in COVID-19 was a consequence
of disequilibrated cytokine network resulting from increased biological activity of TGF-β. …

[HTML][HTML] Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19

M Quirch, J Lee, S Rehman - Journal of medical Internet research, 2020 - jmir.org
… Currently, cytokine storm is … cytokine storm response in SARS-CoV-2 and to explore
the early treatment options for patients who are critically ill with the coronavirus disease (COVID-19) …

Unraveling the mystery of Covid19 cytokine storm: From skin to organ systems

S Garg, M Garg, N Prabhakar, P Malhotra… - Dermatologic …, 2020 - Wiley Online Library
… by severe acute respiratory syndrome-corona virus 2 (SARS-CoV-2). It … , COVID-19 was
considered to just involve lungs causing severe pneumonia, eventually leading to cytokine storm

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine
storm … syndrome, cytokine release syndrome (CRS), and cytokine storm (CS). Hematologic …