JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
… The viral infection could also further promote inhibition of inflammatory signaling pathways
causing immunosuppression [Citation57]. Recently, Bouwman and colleagues reported that …

[HTML][HTML] Activation of STAT3 signaling pathway in the kidney of COVID-19 patients

F Salem, XZ Li, J Hindi, NM Casablanca, F Zhong… - Journal of …, 2022 - Springer
… NF-kB has been considered as a therapeutic target for COVID-19 patients [17]. Therefore,
we evaluated whether the NF-kB pathway was activated in the kidney of COVID-19 patients. p-…

[HTML][HTML] The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
… Camostat Mesylate and nafamostat mesylate are serine protease inhibitors used to treat
pancreatitis and inflammatory diseases could be used to combat NF-κB signalling pathway. …

IL-6 signalling pathway inactivation with siltuximab in patients with COVID-19 respiratory failure: an observational cohort study

G Gritti, F Raimondi, D Ripamonti, I Riva, F Landi… - Medrxiv, 2020 - medrxiv.org
… targeting the IL-6 signalling pathway has been identified as a … hyperinflammation associated
with COVID-19. However, to … target the IL-6 signalling pathway in patients with COVID-19. …

[HTML][HTML] … vesicle associated miRNAs regulate signaling pathways involved in COVID-19 pneumonia and the progression to severe acute respiratory corona virus-2 …

AS Meidert, S Hermann, F Brandes, B Kirchner… - Frontiers in …, 2021 - frontiersin.org
… from patients with COVID-19 pneumonia, COVID-19 ARDS, … With bioinformatically constructed
canonical pathways … differences in molecular signaling between COVID-19 and other …

COVID19: immunopathology, pathophysiological mechanisms, and treatment options

LE van Eijk, M Binkhorst, AR Bourgonje… - The Journal of …, 2021 - Wiley Online Library
pathways and systems involved in the pathophysiology and immunopathogenesis of
COVID-19. … Inhibition of the TLR signalling pathway and thereby decreased cytokine production …

Alzheimer's‐like signaling in brains of COVID19 patients

S Reiken, L Sittenfeld, H Dridi, Y Liu… - Alzheimer's & …, 2022 - Wiley Online Library
… inflammatory signaling and oxidative stress pathways resulting in … of COVID-19 patients,
we observed increased systemic oxidative stress and activation of the TGF-β signaling pathway

[HTML][HTML] Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic targets?

JM Sallenave, L Guillot - Frontiers in immunology, 2020 - frontiersin.org
… An emphasis will be put on host cellular signaling pathways and proteases involved with
a … COVID-19 is a respiratory disease whose aetiologic agent is a novel beta coronavirus (CoV) …

Role of Toll‐like receptors in the pathogenesis of COVID19

S Khanmohammadi, N Rezaei - Journal of medical virology, 2021 - Wiley Online Library
… the TLR4 signaling pathway. Studies have shown that NET formation in COVID-19 patients
… has a higher level in COVID-19 patients and also TLR4 pathway activation in the pulmonary …

[PDF][PDF] A dynamic immune response shapes COVID-19 progression

EZ Ong, YFZ Chan, WY Leong, NMY Lee… - Cell host & …, 2020 - cell.com
… cytokine expression is not the cause of compromised respiratory function in COVID-19
signaling pathway suggests that COVID-19 pathogenesis may be driven by this pathway. If this is …