COVID-19: drug targets and potential treatments

C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
… the severe disease caused by this coronavirus, COVID-19. In this paper, we … signaling
pathways, resulting in inflammation and initiation of cellular immune response. These pathways

Discharge may not be the end of treatment: pay attention to pulmonary fibrosis caused by severe COVID19

C Zhang, Z Wu, JW Li, K Tan, W Yang… - Journal of medical …, 2021 - Wiley Online Library
… of COVID-19 pandemic, the treatment of new cases and critically ill patients is the focus of the
current work. However, COVID-19signaling pathways (TGF- β signal pathway, WNT signal

[HTML][HTML] p38 MAPK inhibition: A promising therapeutic approach for COVID-19

JM Grimes, KV Grimes - Journal of molecular and cellular cardiology, 2020 - Elsevier
pathway, while simultaneously taking advantage of p38 activity to replicate. Therapeutic
inhibition of p38 could therefore attenuate COVID-19 … trials in serious COVID-19 infection. …

Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective

C Lee, WJ Choi - Archives of pharmacal research, 2021 - Springer
… This recognition also leads to the activation of NF-κB and IRF signaling pathways, which
further drives the innate immune system to induce unscheduled cell death following microbial …

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… -κB and MAPK signaling pathways to facilitate viral clearance … the main reasons for the
COVID-19 pathogenesis leading to … of the JAK/STAT signaling pathway. This may further lead to …

Metabolic Perturbations and Severe COVID19 Disease: Implication of Molecular Pathways

E Nigro, F Perrotta, R Polito, V D'Agnano… - International Journal …, 2020 - Wiley Online Library
… This is associated with vascular stiffness, hypertrophy, fibrosis, and remodeling mainly
driven through MAPK dependent signaling pathways. Indeed, insulin stimulates secretion and …

Using a System Pharmacology Method to Search for the Potential Targets and Pathways of Yinqiaosan against COVID19

L Cao, X Jia, H He, Z Wang, Y Zhao… - Journal of …, 2022 - Wiley Online Library
… to treat and prevent COVID-19 using network … COVID-19, this paper uses systems
pharmacology techniques and approaches to forecast the possible targets and signaling pathways of …

Targeting JAK-STAT signaling to control cytokine release syndrome in COVID-19

W Luo, YX Li, LJ Jiang, Q Chen, T Wang… - Trends in pharmacological …, 2020 - cell.com
COVID-19. Several of the cytokines involved in COVID-19 employ a distinct intracellular
signaling pathway … review the possibilities and challenges of targeting the pathway in COVID-19. …

The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19

BG Bagca, CB Avci - Cytokine & growth factor reviews, 2020 - Elsevier
… / STAT signaling pathway, one of the critical cellular signaling pathways involved in the
inflammatory response. This review presents an overview of SARS-CoV-2 and the COVID-19

[HTML][HTML] Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming

J Chen, Y Wang, Y Gao, LS Hu, J Yang, J Wang… - Biomedicine & …, 2020 - Elsevier
… -related pathways, endocrine system pathways were also … PPAR signaling pathway and
adipocytokine signaling pathway… damage through PPAR signaling pathway after H1N1 infection, …