Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
… Severe manifestations of COVID-19 are caused by a combination of direct tissue injury
by viral replication and associated cytokine storm resulting in progressive organ damage. …

Quantification of cytokine storms during virus infections

S Yuan, SC Jiang, ZW Zhang, YF Fu, J Hu… - Frontiers in …, 2021 - frontiersin.org
… We retrieved the cytokine fold change (FC), viral load, and clearance rate data from these …
The best way to prevent a cytokine storm is to reduce the viral load or accelerate the virus

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players …

P Frisoni, M Neri, S D'Errico, L Alfieri… - … Science, Medicine and …, 2022 - Springer
… the expression of multiple cytokines (IL-1β, IL-6, IL-10, IL-15, … strong and diffuse
immunoreactivity for IL-6 and IL-15 in the … Current evidence suggests that a cytokine storm is the …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… of HCQ might mitigate cytokine storm in patients with severe COVID-19. A small French
trial showed significant reductions in viral load and the duration of viral infection for COVID-19 …

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

DM Muema, NA Akilimali, OC Ndumnego, SS Rasehlo… - BMC medicine, 2020 - Springer
… the cytokine storm in the early-treated individuals, suggesting a role for persistent viremia in
maintaining plasma cytokine levels, we checked if the duration to viral load suppression was …

Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates

S Reynard, E Gloaguen, N Baillet… - PLoS Neglected …, 2021 - journals.plos.org
… Here, we studied immune responses depending on the viral loads observed in infected
cynomolgus monkeys. An antiviral treatment allowed the reduction of viral load in some animals …

Modelling of the innate and adaptive immune response to SARS viral infection, cytokine storm and vaccination

C Leon, A Tokarev, A Bouchnita, V Volpert - Vaccines, 2023 - mdpi.com
… leads to a shorter incubation period and higher maximal viral load. … viral loads. In order to
study the emergence and dynamics of cytokine storm, we consider proinflammatory cytokines

Modelling of cytokine storm in respiratory viral infections

C Leon, AA Tokarev, VA Volpert - Computer Research and Modeling, 2022 - hal.science
… In particular, increase of the initial viral load leads to shorter … maximal viral load. In order to
study the emergence and dynamics of cytokine storm, we consider proinflammatory cytokines

[PDF][PDF] Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Y Liu, C Zhang, F Huang, Y Yang, F Wang… - National Science …, 2020 - academic.oup.com
cytokine storm likely occurred in 2019-nCoV-infected patients. There were significant elevations
in 38 out of 48 plasma cytokines… We discovered that 15 cytokines are linearly associated …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
cytokine storm is induced by the virus will be introduced in detail, including the ways in which
cytokines are … related to the viral load, and the degree of the cytokine storm is an essential …