Matrix Metalloproteinase-9 is involved in the fibrotic process in denervated muscles after sciatic nerve trauma and recovery

O Goncharuk, S Savosko, A Tykhomyrov… - … Surgery Part A …, 2023 - thieme-connect.com
MMP-2 and MMP-9 are found in neuromuscular junctions, Schwann's cells, and perineurium
of the denervated muscle … [15] Collectively, these data suggest that ММР-2 and MMP-9 are …

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

DL Rebolledo, D González, J Faundez-Contreras… - Matrix Biology, 2019 - Elsevier
… To evaluate if CTGF has a role in regulating the amount of FAPs, we used total homogenates
from control and denervated muscles for 2 weeks and evaluated PDGFR-α and Tcf4 levels. …

P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC

M Chen, H Chen, Y Gu, P Sun, J Sun, H Yu… - BMC Musculoskeletal …, 2021 - Springer
… and renal failure, and sepsis or in specific muscles due to denervation or inactivity [1,2,3].
The degradation of both myofibrillar and soluble proteins is accelerated during atrophy. …

Urinary titin is not an early biomarker of skeletal muscle atrophy induced by muscle denervation in mice

J Tanihata, S Minamisawa - PLoS One, 2023 - journals.plos.org
… Titin protein is also known to be cleaved by calpain and matrix-metalloproteinase-2 when
protease activity is increased in pathological conditions such as oxidative stress [28, 29]. …

Adipose‐derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model

BK Schilling, MA Schusterman, DY Kim… - Muscle & …, 2019 - Wiley Online Library
… of MMP-2, albeit sparse. The DiR-labeled ASCs did not appear to be localized to the presence
of either Ki67 or MMP-2 … A 2-week investigation of 3 ASC injections into the denervated rat …

Inhibiting Matrix Metalloproteinases Protects Evoked Electromyography Amplitudes and Muscle Tension in the Orbicularis Oris Muscle in a Rat Model of Facial Nerve …

S Wu, L Song, M Yu, C Gong… - Journal of Neuropathology …, 2022 - academic.oup.com
muscle injury (19) and MMP-2 plays a critical role in skeletal muscular atrophy; moreover,
inhibiting MMP-2 … Unlike the neurotransmission that is completely blocked after denervation, …

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers

R Valle-Tenney, DL Rebolledo, KE Lipson, E Brandan - Matrix Biology, 2020 - Elsevier
… Western blot analysis of HIF-1α expression in denervated gastrocnemius muscles at 2, 4
days, 1 week and 2 weeks post denervation. Densitometric analysis of HIF-1α protein levels …

Effects of stretching on the basement membrane structure in the soleus muscle of Wistar rats

Y Kanazawa, T Takahashi, T Higuchi, R Miyachi… - Medical Molecular …, 2023 - Springer
Matrix metalloproteinase 2 (MMP2) activity was evaluated by a gelatin zymography assay
(a… Matrix metalloproteinase 2 (MMP2) localization in the soleus muscle of the control (a, b), …

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

R Sartori, A Hagg, S Zampieri, A Armani… - Science translational …, 2021 - science.org
… (D) Immunoblot and densitometric analysis of p-SMAD1/5/8 protein in TA muscles examined
2 weeks after transfection by electroporation with constructs expressing enhanced green …

Reactive oxygen species in skeletal muscle injury, fatigue, regeneration and ageing: In memory of John Faulkner The role of zinc and matrix metalloproteinases in …

F Ribeiro, X Zhang, Y Wen, N Cacciani… - Free Radical Biology …, 2024 - Elsevier
2B), but accumulation of Zn was detected in muscle … of MMP-9 and TIMP-1 during skeletal
muscle atrophy following long-term disuse induced either by immobilization 41 or denervation