Concept of extremes in vascular aging: from early vascular aging to supernormal vascular aging

S Laurent, P Boutouyrie, PG Cunha, P Lacolley… - …, 2019 - Am Heart Assoc
Laurent et al Early, Normal, and Supernormal Vascular Aging 219 normally defined by the
absence of variables linked to the metabolic syndrome. 21, 22 An alternative way to define …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
… In our review, all four investigated clocks pointed to accelerated aging … -specific age estimation
could aid future efforts for early … The authors found consistent evidence of acceleration in …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
… jointly may point to the mechanisms of accelerated aging. … no evidence that telomerase is a
resilience mechanism for aging. … with aging earlier than average because of early imbalances …

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

DW Belsky, A Caspi, L Arseneault, A Baccarelli… - Elife, 2020 - elifesciences.org
… The test may also help identify individuals with accelerated aging. This might help public …
Earlier we reported from this trial that the intervention (two years of prescribed 25% caloric …

Obesity may accelerate the aging process

V Salvestrini, C Sell, A Lorenzini - Frontiers in endocrinology, 2019 - frontiersin.org
… demonstrated that limited, early presence of obesity and insulin resistance … This suggests
that obesity could accelerate age-related … In conclusion, there is solid evidence that obesity …

Accelerated early vascular aging among adolescents with obesity and/or type 2 diabetes mellitus

JR Ryder, E Northrop, KD Rudser, AS Kelly… - Journal of the …, 2020 - Am Heart Assoc
Background The normal rate of subclinical vascular aging from adolescence to young
adulthood has not been well‐characterized. We conducted a 5‐year longitudinal study among …

Effect of rapamycin on aging and age-related diseases—past and future

R Selvarani, S Mohammed, A Richardson - Geroscience, 2021 - Springer
… that a pharmacological agent could have an impact on aging … implemented early in life
before the negative impact of aging. … is strong evidence for rapamycin’s effect on aging and age-…

Biological Versus Chronological Aging: JACC Focus Seminar

MR Hamczyk, RM Nevado, A Barettino, V Fuster… - Journal of the American …, 2020 - jacc.org
… Multiple inheritable and acquired conditions and diseases can accelerate vascular aging
and lead to an early death. Acquired conditions are frequently caused by an unhealthy lifestyle …

The association of aging biomarkers, interstitial lung abnormalities, and mortality

JL Sanders, RK Putman, J Dupuis, H Xu… - American journal of …, 2021 - atsjournals.org
… of early pulmonary fibrosis and may even precede their development. The evidence that …
, but not all, biomarkers associated with accelerated aging may be helpful in identifying ILA. …

[HTML][HTML] The role of DNA methylation in epigenetics of aging

A Unnikrishnan, WM Freeman, J Jackson… - Pharmacology & …, 2019 - Elsevier
… The strongest evidence that the age-related changes in DNA … accelerated aging are correlated
with accelerated epigenetic … chronological age (r = 0.94) and outperforms earlier iteration …