The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

T Rosenow, LC Mok, L Turkovic… - European …, 2019 - Eur Respiratory Soc
… Lung disease in cystic fibrosis (CF) begins early in life and is characterised by an ongoing
… treatment for early CF lung disease would be warranted. Optimising early intervention and …

Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

KJ Bayfield, TA Douglas, T Rosenow, JC Davies… - Thorax, 2021 - thorax.bmj.com
… techniques in early lung disease, … Cystic Fibrosis Conference. The meeting entitiled ‘Shaping
imaging and functional testing for early disease detection of lung disease in Cystic Fibrosis’…

Structural determinants of long-term functional outcomes in young children with cystic fibrosis

L Turkovic, D Caudri, T Rosenow… - European …, 2020 - Eur Respiratory Soc
… surrogate end-point in early intervention trials, is trying to … -term effects might be expected
from an intervention in early life when … Respiratory Early Surveillance Team for Cystic Fibrosis (…

[HTML][HTML] Development of the gut microbiota in early life: The impact of cystic fibrosis and antibiotic treatment

M Kristensen, SMPJ Prevaes, G Kalkman… - … of Cystic Fibrosis, 2020 - Elsevier
… Patients with Cystic Fibrosis (CF) … early life development of the gut microbial community
composition of children with CF compared to healthy infants and to study the independent effects

The future of cystic fibrosis care: a global perspective

SC Bell, MA Mall, H Gutierrez, M Macek… - The Lancet …, 2020 - thelancet.com
The past six decades have seen remarkable improvements in health outcomes for people
with cystic fibrosis, which was once a fatal disease of infants and young children. However, …

Cystic fibrosis in the year 2020: A disease with a new face

K De Boeck - Acta paediatrica, 2020 - Wiley Online Library
cystic fibrosis (CF) now survive to adulthood, and many countries have instituted CF newborn
screening because early … by mutations in the cystic fibrosis transmembrane conductance …

Impact of newborn screening on outcomes and social inequalities in cystic fibrosis: a UK CF registry-based study

DK Schlüter, KW Southern, C Dryden, P Diggle… - Thorax, 2020 - thorax.bmj.com
… How has newborn screening for cystic fibrosis (CF) affected early outcomes; and has
screening reduced the well documented social inequalities in CF outcomes, whereby children …

Cystic fibrosis: emergence of highly effective targeted therapeutics and potential clinical implications

MA Mall, N Mayer-Hamblett… - American journal of …, 2020 - atsjournals.org
… Several FDA-approved compounds were identified in an early variant of this study,
before medicinal chemistry, but probably do not have sufficient efficacy to warrant further …

A new era for people with cystic fibrosis

MC Bierlaagh, D Muilwijk, JM Beekman… - European Journal of …, 2021 - Springer
… We know that early introduction of therapy targeting the downstream effects of CF is important
for disease severity later in life. For instance, recovery of lower birth weight at the age of …

Cystic fibrosis: a review

T Ong, BW Ramsey - Jama, 2023 - jamanetwork.com
Early lung disease in infants and preschool children with cystic fibrosis: what have we …
Effects of diagnosis by newborn screening for cystic fibrosis on weight and length in the first …