[HTML][HTML] Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

MS Datoo, A Dicko, H Tinto, JB Ouédraogo… - The Lancet, 2024 - thelancet.com
… a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical malaria with …
Here, we report on safety and efficacy of the vaccine in a phase 3 trial enrolling over 4800 …

A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria

SB Sirima, A Ouédraogo, AB Tiono… - Science translational …, 2022 - science.org
… A highly effective malaria vaccine remains elusive … vaccine (PfSPZ Vaccine), a metabolically
active, nonreplicating, whole parasite vaccine demonstrated safety and vaccine efficacy (VE…

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a …

MS Sissoko, SA Healy, A Katile, I Zaidi, Z Hu… - The Lancet Infectious …, 2022 - thelancet.com
… randomised controlled trials of malaria vaccines in adults published between … malaria
vaccines” [MeSH Terms] OR “malaria” [All Fields] AND “vaccines” [All Fields]) OR “malaria vaccines

Correlates of malaria vaccine efficacy

DI Stanisic, MBB McCall - Expert Review of Vaccines, 2021 - Taylor & Francis
efficacy against controlled human malaria infections (CHMI) and against naturally acquired
infections. Expert Opinion: Effective vaccination … disappointing efficacy of malaria vaccine

PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial

D Coulibaly, AK Kone, K Traore, A Niangaly… - …, 2022 - thelancet.com
… ”, “malaria vaccines”, “adults”, AND “clinical trials”. We did not identify studies that assess
the safety and protective efficacy of more than 51,200 unattenuated whole malaria sporozoites …

Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
… effective malaria vaccines are needed. In this review, we discuss malaria vaccine candidates
… : Sanaria’s irradiated sporozoite vaccine (PfSPZ Vaccine), the chemoattenuated sporozoite …

RTS, S/AS01 malaria vaccine—proven safe and effective?

A Björkman, CS Benn, P Aaby… - The Lancet Infectious …, 2023 - thelancet.com
… the RTS,S malaria vaccine, with its strong safety profile and … malaria transmission. The
evidence base included phase 3 trials in seven African countries and an ongoing malaria vaccine

[HTML][HTML] Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled …

MS Datoo, MH Natama, A Somé, O Traoré, T Rouamba… - The Lancet, 2021 - thelancet.com
… a well tolerated safety profile and potent immunogenicity, we initiated a phase 1/2b safety,
immunogenicity, and efficacy trial of this novel pre-erythrocytic malaria vaccine candidate in …

… human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria vaccine …

JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
… of a highly efficacious malaria vaccine. Nevertheless, it is the first head-to-head comparison
of CAF01 with another adjuvant, and our immunological aim—increasing vaccine-induced …

Safety profile of the RTS, S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa

Y Guerra Mendoza, E Garric, A Leach… - Human vaccines & …, 2019 - Taylor & Francis
… The development and deployment of an effective malaria vaccine is considered a further …
a malaria vaccine candidate targeting the circumsporozoite protein and has proven efficacy in …