[HTML][HTML] Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

YK Yeoh, T Zuo, GCY Lui, F Zhang, Q Liu, AYL Li… - Gut, 2021 - gut.bmj.com
… microbiota are known to modulate host immune responses,12 we hypothesised that … immune
responses in COVID-19. Here, we characterised the gut microbiota and immune response

Immune determinants of COVID-19 disease presentation and severity

P Brodin - Nature medicine, 2021 - nature.com
… In this Perspective, I discuss what we know about the immune response to SARS-CoV-2
infection and how this might explain different disease presentations and disease severity by …

Sex differences in immune responses that underlie COVID-19 disease outcomes

T Takahashi, MK Ellingson, P Wong, B Israelow… - Nature, 2020 - nature.com
… The patients were assessed with a locally developed clinical scoring system for disease
severity; (1): admitted and observed without supplementary oxygen; (2) required ≤ 3 l …

Immune responses during COVID-19 infection

C Melenotte, A Silvin, AG Goubet, I Lahmar… - …, 2020 - Taylor & Francis
… Paradoxically, exacerbated or uncontrolled induction of these pro-inflammatory cytokines
can also increase pathogenesis and disease severity as described for SARS-CoV and MERS-…

Viral dynamics and immune correlates of coronavirus disease 2019 (COVID-19) severity

BE Young, SWX Ong, LFP Ng… - … Infectious Diseases, 2021 - academic.oup.com
… The central role of the immune response to SARS-CoV-2 in COVID-19 was evident from
the strong correlation between disease severity and levels of IgG/IgM and inflammatory …

Dysregulation of the immune response in coronavirus disease 2019

L Mohamed Khosroshahi, N Rezaei - Cell Biology International, 2021 - Wiley Online Library
… , including hyper-activation of macrophage and complement system, NLR induction, as well
as NK cells and CTLs exhaustion, could be involved in the disease severity and outcomes. …

[HTML][HTML] Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019

Z Zhu, T Cai, L Fan, K Lou, X Hua, Z Huang… - … of Infectious Diseases, 2020 - Elsevier
… Previous studies have indicated that the severe and aberrant host immune response are
responsible for the severity of COVID-19 (Zhou et al., 2020b). Meanwhile, it was companied by …

Different innate and adaptive immune responses to SARS-CoV-2 infection of asymptomatic, mild, and severe cases

R Carsetti, S Zaffina, E Piano Mortari, S Terreri… - Frontiers in …, 2020 - frontiersin.org
… the basis of the protective immune response in COVID-19, we … analysis of innate and
adaptive immunity in 64 adults with a … of disease severity suggests that the individual immune

Sex differences in immune responses

T Takahashi, A Iwasaki - Science, 2021 - science.org
… This could be related to increased disease severity in this demographic of patients, with
increased viral load driving more B cell activation and antibody production. Alternatively, higher …

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

K Röltgen, AE Powell, OF Wirz, BA Stevens… - Science …, 2020 - science.org
… The objective of this study was to investigate correlations between humoral immune
responses to SARS-CoV-2, including antibodies blocking binding of RBD to the human ACE2 …