… factors with the PAS leads to cleavage of the pre-mRNA (… the template and easily terminated
by XRN2, which degrades the … In the torpedo model, a 5′→3′ exonuclease degrades the …

… polyA + mRNAs and polyA − histone mRNAs, CPSF73 … inhibiting premature termination,
the exonuclease-dead Xrn2 … and/or other factors that generate 5′-PO 4 ends, Xrn2 functions …

… of the RNA from the exonucleolytic degradation and to the interaction … activity of termination
factors. In the Sen1-dependent … decapping of paused Pol II and Xrn2-mediated premature …

… structures protect mRNAs from degradation by exonucleases. … In humans this presumably is
carried out by CLP1 and XRN2. (B) … Extensive biochemical and structural approaches will be …

… downstream of the cleavage site in an XRN2-dependent manner. Targeting the … mRNA
decapping factors and the exonuclease Xrn2 function in widespread premature termination …

… the widespread dependence of protein-coding transcript … the exonuclease XRN2 accelerates
termination but upon XRN2 … disassembly of factors from Pol II that promotes its termination (…

… by its co-factor, the 5′−3′ exonuclease Rat1 14,15 . The … of uncapped pre-mRNA is
prematurely terminated by Rat1 … mRNA degradation and acts with the decapping factors as a …

… Owing to recent extensive efforts to characterize RNA decay … of XRN2, Restrictor and Integrator
in transcription termination, … the exonuclease DIS3 (+) but does not use the exonuclease …

… in the destruction of defective cellular mRNAs and help maintain … mosquitoes, these viruses
are highly prevalent in the tropics and … XRN2 and tubulin were used as positive controls and …

… (especially mRNA synthesis) were a subject of extensive study … decapping factors, and
exonucleases to mRNAs [4]. Histone … the nuclear exosome and Xrn2/Rat1 exonuclease. The pre-…