The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
… Nonetheless, our approach identified a highly potent neutralizing antibody from a patient
sample that had been characterized as having limited antibody response and neutralizing

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
neutralizing antibody, LY-CoV555, derived from a convalescent COVID-19 patient. LY-CoV555
was found to have RBD binding and ACE2 blocking … that neutralizing antibodies have …

[HTML][HTML] Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers

MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019 - cell.com
… of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) …
low serum nAb titers from a total of 78 animals immunized with recombinant native-like (SOSIP…

Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates

L Hangartner, D Beauparlant, E Rakasz… - Science translational …, 2021 - science.org
… in nonhuman primates (NHPs) by a first-generation HIV broadly neutralizing antibody (bnAb) …
concentration at which only half of the animals were protected to avoid potential masking of …

A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant

Z Liu, JFW Chan, J Zhou, M Wang, Q Wang, G Zhang… - Cell research, 2022 - nature.com
… to confer resistance to neutralizing antibodies (nAbs) and sera … potent and durable neutralizing
antibodies against Omicron … nAbs in non-human primates (NHPs) and potently neutralize

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

B Nogal, M Bianchi, CA Cottrell, RN Kirchdoerfer… - Cell reports, 2020 - cell.com
animals. We also show that fusion peptide-specific antibodies are likely responsible for
some neutralizationneutralizing antibodies, enabling a detailed molecular description of the …

AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans

YM Loo, PM McTamney, RH Arends, RA Gasser Jr… - Medrxiv, 2021 - medrxiv.org
… Many individuals with SARS-CoV-2 infection develop neutralizing antibodies to the spike
protein (11, 12), which correlate with protection against symptomatic infection (13). …

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

AD Douglas, GC Baldeviano, J Jin, K Miura… - Nature …, 2019 - nature.com
… We demonstrate that high levels of neutralizing antibodies can achieve protection. This
demonstration of a causal relationship between a defined immunological mechanism and …

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

JH Erasmus, AP Khandhar, AC Walls, EA Hemann… - bioRxiv, 2020 - biorxiv.org
… in nonhuman primates elicited antibody responses that potently neutralized SARS-CoV-2. …
Protection is thought to be mediated by neutralizing antibodies against the S protein 7,8 , as …

Comparison of nonhuman primates identified the suitable model for COVID-19

S Lu, Y Zhao, W Yu, Y Yang, J Gao, J Wang… - Signal transduction and …, 2020 - nature.com
… a Three species of monkeys from two families of nonhuman primates (26 animals
Neutralization assays revealed that virus-specific antibodies from most of the animals had …