JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
… increases with time, more and more efforts are made to pave a way out for the therapeutic
in COVID-19 patients, it drives our focus onto the signaling cascades of the JAK/STAT pathway

[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
… Nafamostat is another TMPRSS2 inhibitor that in a mouse model of COVID-19 reduced
SARS-CoV-2 pulmonary infection [17]. A neutralizing antibody directed against the viral S protein …

[HTML][HTML] Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies

G Ragia, VG Manolopoulos - European journal of clinical pharmacology, 2020 - Springer
COVID-19 test result. Another TMPRSS2 inhibitor with therapeutic potential for treatment of
COVID-19 is … drug for indications unrelated to corona virus and used in Asian countries as a …

[HTML][HTML] The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
… result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition
of NF-κB pathway has a potential therapeutic role in alleviating the severe form of COVID-19. …

JAK inhibition as a new treatment strategy for patients with COVID-19

F Seif, H Aazami, M Khoshmirsafa, M Kamali… - International archives of …, 2020 - karger.com
… other potential JAKinibs and novel anti-inflammatory combination therapies that affect the
JAK-STAT pathway in patients with COVID-19. Since the combination of MTX and baricitinib …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
… , and DHA/EPA, pasireotide), as well as inhibitors targeted toward molecular mediators of
the maladaptive COVID-19 immune response (eg, IL-6, TNF-α, IL-17, JAK, and CDK9). …

[HTML][HTML] p38 MAPK inhibition: A promising therapeutic approach for COVID-19

JM Grimes, KV Grimes - Journal of molecular and cellular cardiology, 2020 - Elsevier
… downregulating a key inhibitory pathway, while simultaneously taking advantage of p38
activity to replicate. Therapeutic inhibition of p38 could therefore attenuate COVID-19 infection. …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
… with the mortality of COVID-19 patients. Both the … treatment available for COVID-19, but
scientists have purposed several treatment options including cytokine inhibitors, JAK inhibitors

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

A Rambaldi, G Gritti, MC Micò, M Frigeni, G Borleri… - Immunobiology, 2020 - Elsevier
… syndrome-associated coronavirus-2 (… pathway activation and has anticoagulant effects.
In this study, the first time a lectin-pathway inhibitor was used to treat COVID-19, six COVID-19

The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19

BG Bagca, CB Avci - Cytokine & growth factor reviews, 2020 - Elsevier
inhibitor, and is known to interfere with the JAK / STAT signaling pathway, one of the critical
cellular signaling pathways … SARS-CoV-2 and the COVID-19 pandemic, and then focuses on …