… that the impact of hepatic BCRP on the overall pharmacokinetics of BCRP substrates cannot
… pharmacokinetics of drugs is probably much larger than at the canalicular side of liver cells. …

… Based on the recognition that hepatic transporters play a pivotal role in hepatic drug … action
of transporters into pharmacokinetic models describing the hepatic clearance of drugs, such …

… -19 drugs with tissue barrier membrane transporters 31 , while … the key hepatocellular
transporters involved in hepatic drug … of in vivo pharmacokinetic properties and potential drug-drug …

… of hepatic drug transporters, their regulatory factors, physiological roles, and their roles in
drug’s … variations in drug transporters may change drug pharmacokinetics, leading to reduce …

… Hepatic drug transporters (DTs) and drug-metabolizing enzymes (DMEs) play pivotal roles
in hepatic drug … proteins drive age-dependent pharmacokinetics. This review compiles the …

… First, we will provide an update of findings on drug-metabolizing enzymes and transporters
in the control of PK, as well as advances in nuclear receptors and noncoding RNAs (ncRNAs…

… ) are hepatic sinusoidal transporters shown to drive hepatic uptake of a wide variety of drugs
… –enzyme interplay in the hepatic clearance and pharmacokinetics of a majority of ECCS 1A …

… to investigate the pharmacokinetics of drug used in patients … differences in pharmacokinetics
and drug-drug interactions … multiple hepatic drug-metabolizing enzymes, transporters and …

… Transporters have also changed basic pharmacokinetic understanding with respect to
models of hepatic elimination. Transporters have been incorporated into hepatic clearance …

… expression and regulation of the basolateral hepatic transporter MPR3/ABCC3 by xenobiotics
… in the pharmacokinetic, pharmacodynamic and/or toxicity of different drugs of clinical use …