Association of history of psychopathology with accelerated aging at midlife

J Wertz, A Caspi, A Ambler, J Broadbent… - … psychiatry, 2021 - jamanetwork.com
… and accelerated aging, we tested whether participants aged 45 years with higher p-factor
scores were rated as looking older by independent observers who rated participants’ age

Accelerating research on biological aging and mental health: Current challenges and future directions

LKM Han, JE Verhoeven, AR Tyrka… - …, 2019 - Elsevier
… Computing age acceleration using cross-sectional and longitudinal data. (A) … , accelerated
aging is established when biological age is over-predicted relative to the chronological age

Psychiatry's opportunity to prevent the rising burden of age-related disease

TE Moffitt, A Caspi - JAMA psychiatry, 2019 - jamanetwork.com
… /high-cost service users had psychiatric disorders by age 15 years. There is a population …
have diagnosable mental disorders as young people, and show accelerated aging as adults…

Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks

C McCrory, G Fiorito, AM O'Halloran, S Polidoro… - …, 2022 - Elsevier
… We examine the association of ELA age acceleration in mid-life using the next-generation …
Having established the relationship of ELA with epigenetic age acceleration in the base …

[HTML][HTML] “GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder

E Protsenko, R Yang, B Nier, V Reus… - … psychiatry, 2021 - nature.com
… Using an epigenetic age estimate of their own derivation, based on 80,000 CpGs, the
group found significant epigenetic age acceleration among depressed patients compared to …

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood

EJ Hamlat, AA Prather, S Horvath… - Developmental …, 2021 - Wiley Online Library
… and other psychiatric disorders (… to age at menarche or epigenetic age acceleration, and
if there is an indirect effect of abuse and/or neglect on epigenetic age acceleration through age

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
… , to uncover novel insights into highly complex psychiatric conditions. Conversely,
comparative analyses of the clocks in psychiatric disorders could offer the chance to dissect the …

Epigenetic Age Acceleration and Disparities in Posttraumatic Stress in Women in Southeast Louisiana: NIMHD Social Epigenomics Program

AK Smith, S Katrinli, DO Cobb, EG Goff… - JAMA Network …, 2024 - jamanetwork.com
… in epigenetic age acceleration among the racial groups for the GrimAge and pace of aging
clocks (Table 2), with Black and American Indian participants having higher age acceleration (…

[HTML][HTML] Mood disorders, accelerated aging, and inflammation: is the link hidden in telomeres?

A Squassina, C Pisanu, R Vanni - Cells, 2019 - mdpi.com
… will be needed to understand if cumulative evaluations of the genetic risk for psychiatric
disorders may be of help in identifying patients who are at a higher risk of accelerated aging. …

Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications

GR Fries, MJ Zamzow, T Andrews, O Pink… - Neuroscience & …, 2020 - Elsevier
… Clearly, inflammation has wide reaching effects both within and outside psychiatric
disorders and a greater understanding of the phenomena will ultimately lead to better clinical …