… treatment reduces viral load and improves clinical outcomes in seropositive hospitalized COVID-19 patients with nonneutralizing or borderline neutralizing antibodies

AT Hooper, S Somersan-Karakaya, SE McCarthy… - Mbio, 2022 - Am Soc Microbiol
… +IMD) is a combination of two neutralizing monoclonal antibodies that bind nonoverlapping
… Although antibodies against SARS-CoV-2 are detected in seropositive individuals in this …

Differential efficacy and safety of anti-SARS-CoV-2 antibody therapies for the management of COVID-19: a systematic review and network meta-analysis

J Deng, K Heybati, HB Ramaraju, F Zhou, D Rayner… - Infection, 2023 - Springer
… of anti-SARS-CoV-2 antibody therapy which can provide … SARS-CoV-2 mAbs are generally
developed from antibodies … the use of mAb combination therapies with reduced mortality, viral …

Noninferiority of Subcutaneous Versus Intravenous Casirivimab/Imdevimab for Outpatient Treatment of SARS-CoV-2 in a Real-World Setting

A Belote, S Reece, S Robinson, H Jensen… - … Antibodies in …, 2022 - liebertpub.com
… Casirivimab/imdevimab (Regen-COV) was one of the promising mAb … antibody combination
vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 …

Safety and efficacy of combination SARS-CoV-2 neutralizing monoclonal antibodies amubarvimab plus romlusevimab in nonhospitalized patients with COVID-19

TH Evering, KW Chew, MJ Giganti, C Moser… - Annals of internal …, 2023 - acpjournals.org
… This randomized, placebo-controlled trial aimed to determine the overall efficacy and
safety of combination therapy with 2 SARS-CoV-2 neutralizing antibodies—amubarvimab and …

[HTML][HTML] Haploidentical CD3+ TCR αβ/CD19+–depleted HSCT for MHC class II deficiency and persistent SARS-CoV-2 pneumonitis

S Ramanathan, L Veramendi-Espinoza… - Journal of Allergy and …, 2023 - Elsevier
… such as SARS-CoV-2–neutralizing antibodies, have become … the combination of casirivimab
plus imdevimab combination (… Because our patient was not eligible for REGEN-COV or any …

COVID-19 therapeutics and vaccines: a race to save lives

I Bebenek, R Bannister, J Dubinion… - Toxicological …, 2022 - academic.oup.com
… The 2 antibodies in the REGEN-COV cocktail, casirivimab … Toxicology studies for REGEN-COV
were designed to support … Single antibodies and the combination were tested through …

A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques

JP Nkolola, J Yu, H Wan, A Chang… - Science Translational …, 2022 - science.org
… The development of monoclonal antibodies (mAbs) that neutralize SARS-CoV-2 offers one
such promising approach for COVID-19 prevention and treatment. These mAbs may have an …

Updated guidance on use and prioritization of monoclonal antibody therapy for treatment of COVID-19 in adolescents

J Wolf, MJ Abzug, BI Anosike, SB Vora… - Journal of the …, 2022 - academic.oup.com
… 10/4206 (0.2%) of those who received REGEN-COV at the authorized dose or a higher
dose [5]… The presence of certain substitutions or combinations of substitutions in the SARS-CoV-2 …

Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern

AA Gorchakov, SV Kulemzin, SV Guselnikov… - Cell Discovery, 2021 - nature.com
… In order to understand whether the antibodies isolated in our study could be combined
together as well as with several published nAbs to form cocktails, we proceeded to compare the …

Efficacy and Safety of Anti-SARS-CoV-2 Monoclonal Antibodies: An Updated Review

G Ravi, M Eerike, VR Konda, D Bisoi… - … Antibodies in …, 2023 - liebertpub.com
REGEN-COV antibody combination and outcomes in outpatients with Covid-19. N Engl J
Med 2021;385(23):e81; doi: 10.1056/NEJMoa2108163 Crossref, Medline, Google Scholar …