Mouse kidney development

AJ Davidson - African Scientist, 2019 - ojs.klobexjournals.com
regulatory molecules must limit the action of Wnt9b. One such factor is Six2, which is
expressed by the cap mesenchyme and functions to suppress the ectopic formation of pre-tubular …

Evolution, kidney development, and chronic kidney disease

RL Chevalier - Seminars in cell & developmental biology, 2019 - Elsevier
… role of this regulatory system in kidney morphogenesis, homeostasis, and regeneration [11]. …
The rise of molecular genetics has afforded new insight into the evolutionary origins of this …

[HTML][HTML] Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu… - Nature …, 2021 - nature.com
… and drivers of early kidney development 4 , that have been essential for the … kidney
development 44 . Of the identified interactions, many were related to stroma-secreted molecules

[HTML][HTML] Regulation of nitric oxide production in the developmental programming of hypertension and kidney disease

CN Hsu, YL Tain - International journal of molecular sciences, 2019 - mdpi.com
development of hypertension and kidney disease. This review will first summarize the regulation
of NO in the kidney… periods of kidney development may produce long-term effects on the …

[HTML][HTML] The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
… array of molecular components that maintain the podocyte tertiary foot processes through
dynamic regulation of the … The risk of developing other kidney diseases including hypertensive …

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

C Guo, G Dong, X Liang, Z Dong - Nature Reviews Nephrology, 2019 - nature.com
… as vascular cell adhesion molecule 1 (VCAM1), intercellular adhesion molecule 1 (ICAM1)
and … of HDAC1 and HDAC3, attenuated kidney injury and the development of renal fibrosis in …

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk

AN Combes, B Phipson, KT Lawlor, A Dorison… - …, 2019 - journals.biologists.com
… knowledge of the molecular basis of kidney development in mice. … understanding of
metanephric kidney development and provides … Transcriptional regulation is a crucial mechanism …

Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas… - Nature Reviews …, 2020 - nature.com
development of such therapies requires an in-depth understanding of the molecular mechanisms
of kidney injury and of why kidney … to kidney injury, including apoptosis and regulated

WNT–β-catenin signalling—a versatile player in kidney injury and repair

SJ Schunk, J Floege, D Fliser, T Speer - Nature Reviews Nephrology, 2021 - nature.com
… In kidney development, WNT4 and WNT9B are of particular … –β-catenin signalling and its
regulation during kidney injury, as … cell adhesion molecules during proteinuric nephropathy 45 . …

Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
kidney injury or maladaptive repair. It is considered as the underlying pathological process
of chronic kidneyKidney's histological structure can be divided into three main compartments…