Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.

K Zhang, JR Chaillet, LA Perkins… - Proceedings of the …, 1990 - National Acad Sciences
By means of low-stringency cross-species hybridization to Southern DNA blots, human c-jun
sequences were used to identify a unique Drosophila melanogaster locus (Djun). The …

Characterization of junD: a new member of the jun proto‐oncogene family.

SI Hirai, RP Ryseck, F Mechta, R Bravo… - The EMBO journal, 1989 - embopress.org
In an extensive screen of a cDNA library prepared from serum‐stimulated mouse NIH 3T3
cells, we identified three distinct jun‐related clones. Two of them were carrying c‐jun and …

A Hierarchy of trans-Acting Factors Modulates Translation of an Activator of Amino Acid Biosynthetic Genes in Saccharomyces cerevisiae

AG Hinnebusch - Molecular and cellular biology, 1985 - Taylor & Francis
The GCN4 gene encodes a positive effector of amino acid biosynthetic genes in
Saccharomyces cerevisiae. Genetic analysis has suggested that GCN4 is regulated by a …

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

TJ Bos, D Bohmann, H Tsuchie, R Tijan, PK Vogt - Cell, 1988 - Elsevier
The jun oncogene of ASV17 is expressed as a 65 kd protein (p65 gag-jun) that contains
partial gag sequences at its amino terminus fused to jun sequences that make up the …

Mechanism of action of a dominant-negative mutant of c-Jun.

PH Brown, TK Chen, MJ Birrer - Oncogene, 1994 - europepmc.org
The AP-1 transcriptional activating complex, made up of Jun and Fos protein, is involved in
controlling many cellular processes such as cell proliferation, differentiation and …

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast

IA Hope, K Struhl - Cell, 1986 - Elsevier
Yeast GCN4 protein binds specifically to the promoters of amino acid biosynthetic genes
and coordinately induces their transcription. Serially deleted GCN4 and hybrid LexA-GCN4 …

[PDF][PDF] Heterodimer formation between CREB and JUN proteins

DM Benbrook, NC Jones - Oncogene, 1990 - ouhsc.edu
DNA binding protein families have been identified that contain a leucine zipper dimerization
motif preceded by a conserved, highly basic domain involved in direct specific interaction …

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

T Deng, M Karin - Genes & development, 1993 - genesdev.cshlp.org
JunB differs considerably from c-Jun in its ability to activate AP-1-responsive genes and
induce oncogenic transformation. We demonstrate that the decreased ability of JunB to …

Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single …

J Schütte, JD Minna, MJ Birrer - Proceedings of the …, 1989 - National Acad Sciences
While the ability of the retroviral oncogene V-jun to transform chicken cells led to its
discovery, the oncogenic potential of its cellular homologue, c-jun, which encodes a …

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping" leucine zippers"

JW Sellers, K Struhl - Nature, 1989 - nature.com
Abstract A STRUCTURAL motif for DNA-binding proteins, the" leucine zipper", has been
proposed for the jun, fos and myc gene products, the yeast transcriptional activator GCN4 …