The promoter region of a replication-dependent histone H3. 2 gene contains a putative DNA
binding site for the Jun oncoprotein within a 32-nucleotide regulatory domain. The hamster …

Before quiescent cells can respond to mitogens and progress through the G1 phase of cell
growth, new messenger RNA synthesis is required1. The G1 phase seems to be a critical …

We have cloned the human jun-6 gene and determined its sequence and transforming and
trans-activating activities. jun-6 is less potent than c-jun in transforming and immortalizing …

Transcription factor AP-1 is constituted by the products of the various fos and jun genes. AP-
1 activity is modulated by second messengers and appears to involve post-translational …

AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and
stimulates transcription of genes responsive to certain growth factors and phorbol esters …

The Jun and Fos oncoproteins belong to the AP-1 family of transcriptional activators and are
believed to induce cellular transformation by inappropriately activating genes involved in …

The product of the protooncogene c-jun is one of the components of the AP-1 transcription
factor complex, which is involved in the control of cell proliferation and differentiation. To …

Regulated transcription by eukaryotic RNA polymerase II (Pol II) requires the functional
interaction of multiple protein factors, some of which presumably interact directly with the …

We have previously described a dominant-negative mutant of cJun that lacks the
transactivation domain (TAD) of cJun and prevents AP-1-mediated transcriptional activation …

Cell transformation leads to alterations in both transcription and DNA replication. Activation
of transcription by the expression of a number of transforming oncogenes is mediated by the …