Blowing up neural repair for stroke recovery: preclinical and clinical trial considerations

NS Ward, ST Carmichael - Stroke, 2020 - Am Heart Assoc
The repair and recovery of the brain after stroke is a field that is emerging in its preclinical
science and clinical trials. However, recent large, multicenter clinical trials have been …

Targets for neural repair therapies after stroke

ST Carmichael - Stroke, 2010 - Am Heart Assoc
Studies of neural repair after stroke have developed from a relatively small number of
laboratories doing highly creative discovery science to a field in which reproducible …

Principles of neural repair and their application to stroke recovery trials

DJ Lin, SC Cramer - Seminars in neurology, 2021 - thieme-connect.com
Neural repair is the underlying therapeutic strategy for many treatments currently under
investigation to improve recovery after stroke. Repair-based therapies are distinct from acute …

Neurorepair versus neuroprotection in stroke

O Hurtado, JM Pradillo, D Alonso-Escolano… - Cerebrovascular …, 2006 - karger.com
Stroke is the second to third leading cause of death and the main cause of severe, long-term
disability in adults. However, treatment is almost reduced to fibrinolysis, a therapy useful in a …

Translating the frontiers of brain repair to treatments: starting not to break the rules

ST Carmichael - Neurobiology of disease, 2010 - Elsevier
The field of neural repair in stroke has identified cellular systems of reorganization and
possible molecular mechanisms. Conceptual barriers now limit the generation of clinically …

Restoring brain function after stroke—bridging the gap between animals and humans

NS Ward - Nature Reviews Neurology, 2017 - nature.com
Stroke is the leading cause of complex adult disability in the world. Recovery from stroke is
often incomplete, which leaves many people dependent on others for their care. The …

Neuroplasticity and brain repair after stroke

SC Cramer, JD Riley - Current opinion in neurology, 2008 - journals.lww.com
A wide range of therapies shows promise for improving poststroke brain repair. Insights into
the neurobiology of brain repair after stroke in animals and in humans continue to accrue …

Clinically applicable experimental design and considerations for stroke recovery preclinical studies

VT Karamyan - Neural Repair: Methods and Protocols, 2023 - Springer
Abstract Development of stroke recovery therapies is an active field of research and
represents an opportunity to reduce the global impact of stroke as the leading cause of …

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

DJ Gladstone, SE Black, AM Hakim - Stroke, 2002 - Am Heart Assoc
Background—Neuroprotective drugs for acute stroke have appeared to work in animals,
only to fail when tested in humans. With the failure of so many clinical trials, the future of …

Issues in clinical trial methodology for brain repair after stroke

SC Cramer - Brain repair after stroke, 2010 - books.google.com
Stroke remains a leading cause of adult disability, the third greatest cause of death in the US
(the second greatest cause in the world), and the most common neurologic reason for …