A bacterial pigment provides cross-species protection from H2O2- and neutrophil-mediated killing

Y Liu, EA McQuillen, PSJB Rana… - Proceedings of the …, 2024 - National Acad Sciences
Bacterial infections are often polymicrobial. Pseudomonas aeruginosa and Staphylococcus
aureus cause chronic co-infections, which are more problematic than mono-species …

Cross-Species Protection to Innate Immunity Mediated by A Bacterial Pigment

Y Liu, EA McQuillen, PSJB Rana, ES Gloag… - bioRxiv, 2023 - biorxiv.org
Bacterial infections are often polymicrobial. Pseudomonas aeruginosa and Staphylococcus
aureus cause chronic co-infections, which are more problematic than mono-species …

Pseudomonas aeruginosa induces pigment production and enhances virulence in a white phenotypic variant of Staphylococcus aureus

V Antonic, A Stojadinovic, B Zhang… - Infection and Drug …, 2013 - Taylor & Francis
Staphyloxanthin is a virulence factor which protects Staphylococcus aureus in stress
conditions. We isolated two pigment variants of S. aureus and one strain of Pseudomonas …

Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

GY Liu, A Essex, JT Buchanan, V Datta… - The Journal of …, 2005 - rupress.org
Golden color imparted by carotenoid pigments is the eponymous feature of the human
pathogen Staphylococcus aureus. Here we demonstrate a role of this hallmark phenotype in …

CspA regulation of Staphylococcus aureus carotenoid levels and σB activity is controlled by YjbH and Spx

NP Donegan, AC Manna, CW Tseng… - Molecular …, 2019 - Wiley Online Library
Staphyloxanthin, a carotenoid in S. aureus, is a powerful antioxidant against oxidative
stresses. The crtOPQMN operon driving pigment synthesis is under the control of σB. CspA …

The Staphylococcus aureus AirSR two-component system mediates reactive oxygen species resistance via transcriptional regulation of staphyloxanthin production

JW Hall, J Yang, H Guo, Y Ji - Infection and immunity, 2017 - Am Soc Microbiol
Staphylococcus aureus is an important opportunistic pathogen and is the etiological agent of
many hospital-and community-acquired infections. The golden pigment, staphyloxanthin, of …

Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate

S Leejae, L Hasap… - Journal of medical …, 2013 - microbiologyresearch.org
Staphyloxanthin is the eponymous feature of the human pathogen Staphylococcus aureus,
and the pigment promotes resistance to reactive oxygen species and host neutrophil-based …

Pseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production

TA Van Laar, S Esani, TJ Birges, B Hazen, JM Thomas… - Msphere, 2018 - Am Soc Microbiol
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium that can cause severe
opportunistic infections. The principal redox buffer employed by this organism is glutathione …

Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress

A Clauditz, A Resch, KP Wieland, A Peschel… - Infection and …, 2006 - Am Soc Microbiol
Staphyloxanthin is a membrane-bound carotenoid of Staphylococcus aureus. Here we
studied the interaction of staphyloxanthin with reactive oxygen substances (ROS) and …

Role of SigB and Staphyloxanthin in Radiation Survival of Staphylococcus aureus

MK Pannu, DA Hudman, NJ Sargentini, VK Singh - Current microbiology, 2019 - Springer
Staphylococcus aureus is a potent human pathogen. The virulence of this bacterium
depends on a multitude of factors that it produces. One such virulence factor is the golden …