cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2α kinase and histidyl-tRNA synthetase-related domains required …
E Sattlegger, AG Hinnebusch, IB Barthelmess - Journal of Biological …, 1998 - ASBMB
Based on characteristic amino acid sequences of kinases that phosphorylate the α subunit
of eukaryotic translation initiation factor 2 (eIF2α kinases), degenerate oligonucleotide …
of eukaryotic translation initiation factor 2 (eIF2α kinases), degenerate oligonucleotide …
Molecular Analysis of GCN3, a Translational Activator of GCN4: Evidence for Posttranslational Control of GCN3 Regulatory Function
EM Hannig, AG Hinnebusch - Molecular and cellular biology, 1988 - Taylor & Francis
GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in
Saccharomyces cerevisiae. The GCN3 product is a positive regulator required for increased …
Saccharomyces cerevisiae. The GCN3 product is a positive regulator required for increased …
Mutations activating the yeast eIF-2a kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases
M Ramirez, RC Wek, CRV De Aldana… - … and cellular biology, 1992 - Am Soc Microbiol
The protein kinase GCN2 stimulates expression of the yeast transcriptional activator GCN4
at the translational level by phosphorylating the α subunit of translation initiation factor 2 (eIF …
at the translational level by phosphorylating the α subunit of translation initiation factor 2 (eIF …
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2
S Zhu, AY Sobolev, RC Wek - Journal of Biological Chemistry, 1996 - ASBMB
In yeast, starvation for amino acids stimulates GCN2 phosphorylation of the α subunit of
eukaryotic initiation factor-2 (eIF-2). Phosphorylation of eIF-2α induces the translational …
eukaryotic initiation factor-2 (eIF-2). Phosphorylation of eIF-2α induces the translational …
Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2α kinase activities of GCN2
M Garcia-Barrio, J Dong, VA Cherkasova… - Journal of Biological …, 2002 - ASBMB
Protein kinase GCN2 regulates translation initiation by phosphorylating eukaryotic initiation
factor 2α (eIF2α), impeding general protein synthesis but specifically inducing translation of …
factor 2α (eIF2α), impeding general protein synthesis but specifically inducing translation of …
Translation of the Yeast Transcriptional Activator GCN4 Is Stimulated by Purine Limitation: Implications for Activation of the Protein Kinase GCN2
RJ Rolfes, AG Hinnebusch - Molecular and cellular biology, 1993 - Taylor & Francis
The transcriptional activator protein GCN4 is responsible for increased transcription of more
than 30 different amino acid biosynthetic genes in response to starvation for a single amino …
than 30 different amino acid biosynthetic genes in response to starvation for a single amino …
The histidyl-tRNA synthetase-related sequence in the eIF-2α protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for …
SA Wek, S Zhu, RC Wek - Molecular and cellular biology, 1995 - Am Soc Microbiol
Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-
tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown …
tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown …
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to …
RC Wek, BM Jackson… - Proceedings of the …, 1989 - National Acad Sciences
The GCN2 protein of Saccharomyces cerevisiae stimulates the expression of amino acid
biosynthetic genes under conditions of amino acid starvation by derepressing GCN4, a …
biosynthetic genes under conditions of amino acid starvation by derepressing GCN4, a …
Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase
I Roussou, G Thireos, BM Hauge - Molecular and cellular biology, 1988 - Am Soc Microbiol
GCN4 protein mediates the transcriptional activation of amino acid biosynthetic genes in
Saccharomyces cerevisiae by specifically binding to DNA sequences in their 5′-regulatory …
Saccharomyces cerevisiae by specifically binding to DNA sequences in their 5′-regulatory …
Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression
RC Wek, M Ramirez, BM Jackson… - Molecular and cellular …, 1990 - Am Soc Microbiol
GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast
Saccharomyces cerevisiae, GCN2, a translational activator of GCN4 expression, contains a …
Saccharomyces cerevisiae, GCN2, a translational activator of GCN4 expression, contains a …
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