Objective—Hemodynamics plays a critical role in atherogenesis, but the association
between flow pattern and preferential localization of lesion is not fully understood. We …

Following surgical induction of aortic valve regurgitation (AR), extensive atherosclerotic
plaque development along the descending thoracic and abdominal aorta of Ldlr−/− mice …

Objective: The probability of aortic complications in patients with bicuspid aortic valve is
higher in association with aortic regurgitation (AR) compared with aortic stenosis (AS) or …

Figure 1. Morphology of endothelial cells and atherosclerotic plaques in the arch region of
the mouse aorta. The greater curvature of the aortic arch and the straight region of the aorta …

Background and aims High blood pressure and reduced aortic compliance are associated
with increased atherosclerotic plaque accumulation in humans. Animal studies support …

Despite considerable evidence suggesting that hypertension contributes to the development
and progression of atherosclerosis, the causative links remain unclear. We have tested the …

Atherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and
129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that …

Background Aortic valve regurgitation is usually caused by impaired coaptation of the aortic
valve cusps during diastole. Hypercholesterolemia produces aortic valve lipid deposition …

Background Experimental animal atherosclerosis models are frequently regarded as an
adequate surrogate for human vascular disease. The external validity of these models …

Aortic blood flow patterns are closely linked to the morphology and function of the left
ventricle, aortic valve and aorta. These flow patterns demonstrate the exceptional …