Rationale: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient
mice are predisposed to the development of obesity and metabolic dysfunction. The …

ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in reverse cholesterol
transport and exhibits anti-atherosclerosis effects. Some microRNAs (miRs) regulate ABCA1 …

Background Cholesterol efflux from cells to apolipoprotein A‐I (apoA‐I) acceptors via the
ATP‐binding cassette transporters ABCA 1 and ABCG 1 is thought to be central in the …

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid …

Efflux of cholesterol from peripheral tissues followed by its subsequent transport to the liver
is proposed as an antiatherogenic mechanism [1]. The principal molecules involved in the …

Rationale Macrophage accumulation of cholesterol leads to foam cell formation which is a
major pathological event of atherosclerosis. Recent studies have shown that microRNA …

Macrophages play a crucial role in the pathogenesis of atherosclerosis, but the molecular
mechanisms remain poorly understood. Here we show that microRNA-34a (miR-34a) is a …

Hazen and Smith An Antiatherosclerotic Signaling Cascade 949 low-circulating systemic
levels. 16 The limited bioavailability of ingested anthocyanins has raised questions of a …

As an important regulator of macrophage cholesterol efflux and HDL biogenesis, miR-33 is a
promising target for treatment of atherosclerosis, and numerous studies demonstrate that …

miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor.
Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism …