Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence
of nutrient catabolism. The balance between ROS production and elimination allows to …

SD-lactoylglutathione (SDL) is an intermediate of the glutathione-dependent metabolism of
methylglyoxal (MGO) by glyoxalases. MGO is an electrophilic compound that is inevitably …

Glyoxalase II, the second of 2 enzymes in the glyoxalase system, is a
hydroxyacylglutathione hydrolase that catalyses the hydrolysis of S‐d‐lactoylglutathione to …

The health-promoting properties of natural plant bioactive compounds are mainly
attributable to their ability to counteract oxidative stress. This is considered a major causative …

Methylglyoxal (MGO) is a toxic, highly reactive metabolite derived mainly from glucose and
amino acids degradation. MGO is also one of the prime precursors for advanced glycation …

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of
glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation …

Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates
of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the …

Glycation refers to the covalent binding of sugar molecules to macromolecules, such as
DNA, proteins, and lipids in a non-enzymatic reaction, resulting in the formation of …

Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …

Uremic sarcopenia is a serious clinical problem associated with physical disability and
increased morbidity and mortality. Methylglyoxal (MG) is a highly reactive, dicarbonyl uremic …