Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers cytokine-
mediated inflammation, leading to a myriad of clinical presentations in COVID-19. The SARS …

The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …

Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great
challenges to the world. More and more studies have shown that patients with severe …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
(VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation …

Many patients with severe COVID-19 suffer from pneumonia and the elucidation of the
mechanisms underlying the development of this severe condition is important. The in vivo …

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for
coronavirus disease 2019 (COVID-19) that emerged in human populations recently …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …

The accessory proteins of coronaviruses are essential for virus–host interactions and the
modulation of host immune responses. It has been reported that accessory protein ORF3a …

Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the
Spike protein despite there are other viral proteins with important roles in COVID-19 …