While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an
attractive avenue for anticancer research owing to the multifactorial nature of cancer itself …

Diarypentanoids are commonly considered as monocarbonyl analogues of curcumin. Since
the discovery of this compound in 1962, twenty one diarylpentanoids have been isolated …

Background: Curcumin is a polyphenolic natural compound with multiple targets that used
for the prophylaxis and treatment of some type of cancers like cervical and pancreatic …

Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …

Developing anticancer agents by a prooxidant strategy has attracted increasing attention in
recent years, although it is not conventional in medicinal chemistry and is completely …

We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced
p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and …

In an effort to study curcumin analogues as an alternative to improve the therapeutic efficacy
of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and …

Cancer is a diverse class of diseases characterized by uncontrolled cell growth that
constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress …

Introduction: Terpenoids constitute the largest class of natural products and are a rich
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …

Cancer is one of the leading causes of death and significantly burdens the healthcare
system. Due to its prevalence, there is undoubtedly an unmet need to discover novel …