Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an
important role in the functioning of the body at the cellular level and participate in many …

Sirtuins, commonly known as NAD+-dependent class III histone deacetylase enzymes, have
been extensively studied to evaluate their potential role in different disease states. Based on …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …

The protein acetylation of either the α-amino groups of amino-terminal residues or of internal
lysine or cysteine residues is one of the major posttranslational protein modifications that …

The sirtuins (SIRTs) are a family of enzymes from the group of NAD+-dependent
deacetylases. Through the reaction of splitting the acetyl group of various transcription …

Sirtuins are NAD+‐dependent protein deacylases that cleave off acetyl, as well as other acyl
groups, from the ε‐amino group of lysines in histones and other substrate proteins. Seven …

Earlier analyses on the sirtuin family of histone deacetylases and its well-known member
SIRT1 had their primary focus mostly on the identification of cellular targets exploring …

The identification of mammalian sirtuins (SIRTs; silent information regulator transcript) with
close homology to Sir2 from yeast is a recent discovery, which has ignited the field of caloric …

Transcription is regulated by acetylation/deacetylation reactions of histone and nonhistone
proteins mediated by enzymes called KATs and HDACs, respectively. As a major …