A quinquennial review on recent advancements and developments in search of anti-malarial agents

TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - ingentaconnect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

A comprehensive review on synthetic approach for antimalarial agents

A Kumar, D Paliwal, D Saini, A Thakur… - European journal of …, 2014 - Elsevier
Malaria has emerged as a major health problem worldwide after the appearance of resistant
strains of Plasmodium falciparum to the most of antimalarial drugs. The development of …

[PDF][PDF] Antimalarial drug development: past to present scenario

M Dhanawat, N Das, RC Nagarwal… - Mini Reviews in …, 2009 - researchgate.net
Malaria is a global health problem that needs attention of drug discovery scientists to
investigate novel compounds with high drug efficacy, safety and low cost to counter the …

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

PN Kalaria, SC Karad, DK Raval - European journal of medicinal chemistry, 2018 - Elsevier
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

Design of antimalarial agents based on natural products

J Jampilek - Current Organic Chemistry, 2017 - ingentaconnect.com
Background: Despite the successes achieved recently in the treatment of various infectious
diseases, the morbidity and mortality associated with malaria remain major burdens …

Synthetic medicinal chemistry of selected antimalarial natural products

V Kumar, A Mahajan, K Chibale - Bioorganic & medicinal chemistry, 2009 - Elsevier
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial
agents in the fight against malaria. This has been well demonstrated in the case of quinine …

Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria

S Kumar, RK Singh, B Patial, S Goyal… - Journal of Enzyme …, 2016 - Taylor & Francis
Malaria is a major public health problem all over the world, particularly in tropical and
subtropical countries due to the development of resistance and most deadly infection is …

[HTML][HTML] Search for structurally diverse heterocyclic analogs as dual-acting antimalarial and antileishmanial agents: An overview

S Dey, S Johri, M Abirami, BK Kumar… - European Journal of …, 2022 - Elsevier
Infections caused by protozoan parasites continue to be a significant cause of morbidity and
mortality across the globe, with malaria and leishmaniasis forming the fulcrum of these …

Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation

DJ Sullivan, N Kaludov, MN Martinov - Malaria Journal, 2011 - Springer
Background Developing resistance towards existing anti-malarial therapies emphasize the
urgent need for new therapeutic options. Additionally, many malaria drugs in use today have …