SARS-CoV-2 accessory protein ORF7b mediates tumor necrosis factor-α-induced apoptosis in cells

R Yang, Q Zhao, J Rao, F Zeng, S Yuan, M Ji… - Frontiers in …, 2021 - frontiersin.org
The accessory proteins of coronaviruses are essential for virus–host interactions and the
modulation of host immune responses. It has been reported that accessory protein ORF3a …

SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Y Ren, T Shu, DI Wu, J Mu, C Wang, M Huang… - Cellular & molecular …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing
pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus …

Ubiquitination of SARS-CoV-2 ORF7a prevents cell death induced by recruiting BclXL to activate ER stress

Z Liu, Y Fu, Y Huang, F Zeng, J Rao, X Xiao… - Microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19), which has emerged in the last 2 years. The …

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

BD López-Ayllón, A de Lucas-Rius… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins
encoded in its genome. Their roles during infection are still not completely understood. In …

[HTML][HTML] Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

T García-García, R Fernández-Rodríguez, N Redondo… - IScience, 2022 - cell.com
Summary SARS-CoV-2, the causative agent of the present COVID-19 pandemic, possesses
eleven accessory proteins encoded in its genome, and some have been implicated in …

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for
coronavirus disease 2019 (COVID-19) that emerged in human populations recently …

Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

Z Cao, H Xia, R Rajsbaum, X Xia, H Wang… - Cellular & molecular …, 2021 - nature.com
Understanding interactions between the host and SARS-CoV-2 is essential for developing
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …

[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion

M Zandi, M Shafaati, D Kalantar-Neyestanaki… - Biomedicine & …, 2022 - Elsevier
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …

SARS-CoV-2 ORF8 forms intracellular aggregates and inhibits IFNγ-induced antiviral gene expression in human lung epithelial cells

H Geng, S Subramanian, L Wu, HF Bu… - Frontiers in …, 2021 - frontiersin.org
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …