Abstract Purpose of Review Heart failure (HF) is a structural or functional cardiac
abnormality which leads to failure of the heart to deliver oxygen commensurately with the …

Skeletal muscle abnormalities are well-established in patients with heart failure from an
early stage in the progression of the disease and contribute to their symptoms and the …

Exercise capacity is lowered in patients with heart failure, which limits their daily activities
and also reduces their quality of life. Furthermore, lowered exercise capacity has been well …

Chronic heart failure (CHF) is a complex clinical syndrome leading to exercise intolerance
due to muscular fatigue and dyspnea. Hemodynamics fail to explain the reduced exercise …

Physiologic endurance exercise performance is primarily limited by cardiac function. In
patients with heart failure, there is dissociation between cardiac performance and exercise …

Abstract Purpose of Review To discuss the impact of deleterious changes in skeletal muscle
morphology and function on exercise intolerance in patients with heart failure with reduced …

Heart failure is associated with reduction of exercise capacity that cannot be solely ascribed
to reduced maximal oxygen uptake (V˙ O2max). Therefore, research has focused on …

BACKGROUND The purpose of this study was to investigate the prevalence of skeletal
muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in …

Heart failure (HF) remains a major challenge in Western countries with up to 2% of the
population being affected. Co-morbidities have a huge impact on the clinical course and on …

Chronic heart failure (CHF) patients frequently experience impaired exercise tolerance due
to skeletal muscle fatigue. Studies suggest that this in part is due to intrinsic alterations in …