Curcumin inspired synthesis of unsymmetrical diarylpentanoids with highly potent anti-parasitic activities: in silico studies and DFT-based stereochemical calculation

ZU Din, A dos Santos, MA Trapp, D Lazarin-Bidóia… - …, 2016 - pubs.rsc.org
Unsymmetrical diarylpentanoid analogues of curcumin have been synthesized by Claisen–
Schmidt condensation of different aldehydes and ketones. Anisaldehyde treated with 2 …

N-substituted noscapine derivatives as new antiprotozoal agents: Synthesis, antiparasitic activity and molecular docking study

KB Harikandei, P Salehi, SN Ebrahimi… - Bioorganic …, 2019 - Elsevier
Novel N-substituted noscapine derivatives were synthesized by a three-component Strecker
reaction of cyclic ether of N-nornoscapine with varied aldehydes, in the presence of cyanide …

[HTML][HTML] Discovery of New Hits as Antitrypanosomal Agents by In Silico and In Vitro Assays Using Neolignan-Inspired Natural Products from Nectandra leucantha

SC Araujo, FS Sousa, TA Costa-Silva, AG Tempone… - Molecules, 2021 - mdpi.com
In the present study, the phytochemical study of the n-hexane extract from flowers of
Nectandra leucantha (Lauraceae) afforded six known neolignans (1–6) as well as one new …

Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

AH Ramli, SM Mohd Faudzi - Archiv der Pharmazie, 2023 - Wiley Online Library
Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …

[HTML][HTML] Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

AH Ramli, P Swain, MSAM Fahmi, F Abas, SW Leong… - Heliyon, 2024 - cell.com
Malaria remains a major public health problem worldwide, including in Southeast Asia.
Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug …

[HTML][HTML] The structure design of biotransformed unsymmetrical nitro-contained 1, 5-diaryl-3-oxo-1, 4-pentadienyls for the anti-parasitic activities

ZU Din, D Lazarin-Bidoia, V Kaplum, FP Garcia… - Arabian Journal of …, 2019 - Elsevier
Abstract Two 1, 5-diaryl-3-oxo-1, 4-pentadienyls (1 and 2) having nitro group attached
exhibited potent anti-parasitic activity when evaluated against Trypanosoma cruzi and …

Molecular dynamics simulation and docking studies of selenocyanate derivatives as anti-leishmanial agents

M Iman, H Bakhtiari Kaboutaraki… - … Chemistry & High …, 2016 - ingentaconnect.com
Background: Selenocyanate derivatives have been recently presented as potent anti-
leishmanial agents. Objective: In this research, thirty five selenocyanate and diselenide …

Symmetrical and unsymmetrical substituted 2, 5-diarylidene cyclohexanones as anti-parasitic compounds

ZU Din, MA Trapp, LS de Medeiros… - European Journal of …, 2018 - Elsevier
Symmetrical and unsymmetrical bis-aryl-α, β-unsaturated ketones were synthesized in
moderate to excellent yield by treating cyclohexanone with various aldehydes …

Identification In Silico and In Vitro of Novel Trypanosomicidal Drug‐Like Compounds

JA Castillo‐Garit, O del Toro‐Cortés… - Chemical biology & …, 2012 - Wiley Online Library
Atom‐based bilinear indices and linear discriminant analysis are used to discover novel
trypanosomicidal compounds. The obtained linear discriminant analysis‐based quantitative …

[HTML][HTML] Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches

CM Clemente, SM Robledo, S Ravetti - BMC Complementary Medicine …, 2022 - Springer
Introduction Despite the number of deaths and the significant economic and social costs
associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs …