Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells

I Schulien, J Kemming, V Oberhardt, K Wild… - Nature medicine, 2021 - nature.com
Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …

Longitudinal systemic and mucosal immune responses to SARS-CoV-2 infection

PF Wright, AC Prevost-Reilly… - The Journal of …, 2022 - academic.oup.com
Background A longitudinal study was performed to determine the breadth, kinetics, and
correlations of systemic and mucosal antibody responses to severe acute respiratory …

SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence

S Boppana, K Qin, JK Files, RM Russell, R Stoltz… - PLoS …, 2021 - journals.plos.org
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate
neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S …

CD8+ T-cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

AD Redd, A Nardin, H Kared, EM Bloch… - Open Forum …, 2021 - academic.oup.com
This study examined whether CD8+ T-cell responses from coronavirus disease 2019
convalescent individuals (n= 30) potentially maintain recognition of the major severe acute …

[HTML][HTML] Impact of SARS-CoV-2 infection on the profiles and responses of innate immune cells after recovery

V Ruenjaiman, P Sodsai, P Kueanjinda… - Journal of Microbiology …, 2022 - Elsevier
Backgrounds SARS-CoV-2 infection results in a broad spectrum of clinical outcomes,
ranging from asymptomatic to severe symptoms and death. Most COVID-19 pathogenesis is …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

[HTML][HTML] Longitudinal assessment of anti-SARS-CoV-2 antibody dynamics and clinical features following convalescence from a COVID-19 infection

C Gerhards, M Thiaucourt, M Kittel, C Becker… - International Journal of …, 2021 - Elsevier
Introduction The longevity of antibody levels against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and the duration of immunity are current topics of major …

[HTML][HTML] High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

D Schub, V Klemis, S Schneitler, J Mihm, PM Lepper… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Patients infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS …

[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

BJ Meckiff, C Ramírez-Suástegui, V Fajardo, SJ Chee… - Cell, 2020 - cell.com
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

SSF Nielsen, LK Vibholm, I Monrad, R Olesen… - …, 2021 - thelancet.com
Abstract Background The SARS-CoV-2 pandemic currently prevails worldwide. To
understand the immunological signature of SARS-CoV-2 infections and aid the search and …